Brensocatib Leads to Lower Rate of Pulmonary Exacerbations in Bronchiectasis
THURSDAY, April 24, 2025 -- For patients with bronchiectasis, brensocatib leads to a lower annualized rate of pulmonary exacerbations, according to a study published in the April 24 issue of the New England Journal of Medicine.
James D. Chalmers, M.B., Ch.B., Ph.D., from the University of Dundee in the United Kingdom, and colleagues conducted a phase 3, double-blind trial involving patients with bronchiectasis who were randomly assigned to receive brensocatib (10 mg or 25 mg once per day) or placebo (1:1:1 ratio for adults; 2:2:1 ratio for adolescents).
A total of 1,680 adults and 41 adolescents were randomly assigned to brensocatib or placebo. The researchers found that the annualized rate of pulmonary exacerbations was 1.02, 1.04, and 1.29 in the 10-mg brensocatib group, 25-mg brensocatib group, and placebo group, respectively (rate ratios, 0.79 and 0.81 with the 10-mg and 25-mg brensocatib doses, respectively, versus placebo). For the time to first exacerbation, the hazard ratio was 0.81 and 0.83 with the 10-mg and 25-mg doses, respectively. At week 52, 48.5 percent of patients in each brensocatib group remained exacerbation-free, compared with 40.3 percent in the placebo group (rate ratios, 1.20 and 1.18 with the 10-mg and 25-mg doses, respectively). Forced expiratory volume in one second had decreased by 50, 24, and 62 mL with the 10-mg dose, 25-mg dose, and placebo, respectively, at week 52, with the reduction significant for the 25-mg dose. The incidence of adverse events was similar across groups. There was a higher incidence of hyperkeratosis with brensocatib.
"These results show that inhibiting dipeptidyl peptidase 1 with brensocatib -- and thereby targeting neutrophilic inflammation -- results in meaningful improvements in outcomes in patients with bronchiectasis," the authors write.
The study was funded by Insmed, which is developing brensocatib.
Abstract/Full Text (subscription or payment may be required)
Editorial (subscription or payment may be required)
Disclaimer: Statistical data in medical articles provide general trends and do not pertain to individuals. Individual factors can vary greatly. Always seek personalized medical advice for individual healthcare decisions.
© 2025 HealthDay. All rights reserved.
Read this next
Lung Cancer Screening Beneficial to Age 80 for Candidates Fit for Surgery
FRIDAY, Sept. 12, 2025 -- People aged 75 to 80 years at last screen who are diagnosed with screen-detected lung cancer (LC) have lower overall survival, but those undergoing...
Sex Differences Seen in Characteristics, Course of Schizophrenia, Bipolar Disorder
FRIDAY, Sept. 12, 2025 -- Significant sex differences are seen in the characteristics and course of schizophrenia (SZ) and bipolar disorder (BD), according to a study published...
Potentially Inappropriate Medications Linked to Frailty at Cancer Diagnosis
FRIDAY, Sept. 12, 2025 -- For patients with newly diagnosed cancer, an increasing number of potentially inappropriate medications (PIMs), as identified by the Geriatric Oncology...
More news resources
- FDA Medwatch Drug Alerts
- Daily MedNews
- News for Health Professionals
- New Drug Approvals
- New Drug Applications
- Drug Shortages
- Clinical Trial Results
- Generic Drug Approvals
Subscribe to our newsletter
Whatever your topic of interest, subscribe to our newsletters to get the best of Drugs.com in your inbox.