Antidepressant Use May Speed Up Cognitive Decline in Patients With Dementia
WEDNESDAY, March 5, 2025 -- Current antidepressant use is associated with faster cognitive decline in patients with dementia, according to a study published online Feb. 25 in BMC Medicine.
Minjia Mo, Ph.D., from the Karolinska Institutet in Stockholm, and colleagues examined the association between antidepressants and cognitive decline in patients with dementia in a national cohort study. Data were included for 18,740 patients, of whom 22.8 percent received at least one prescription for an antidepressant.
The researchers found that 11,912 prescriptions for antidepressants were issued during follow-up, with selective serotonin reuptake inhibitors (SSRI) being the most common (64.8 percent). Compared with nonuse, there was an association for antidepressant use with faster cognitive decline (β = −0.30 points/year), especially for sertraline, citalopram, escitalopram, and mirtazapine (β = −0.25, −0.41, −0.76, and −0.19 points/year, respectively). Patients with severe dementia (initial Mini-Mental State Examination scores 0 to 9) had a stronger association. A greater rate of decline was seen for escitalopram than sertraline. Dose response of SSRIs on greater cognitive decline and higher risks for severe dementia, all-cause mortality, and fracture were seen compared with nonuse.
"Our study cannot distinguish whether these findings are due to the antidepressants or the underlying psychiatric indication," the authors write.
Disclaimer: Statistical data in medical articles provide general trends and do not pertain to individuals. Individual factors can vary greatly. Always seek personalized medical advice for individual healthcare decisions.

© 2025 HealthDay. All rights reserved.
Read this next
Personal Storytelling During Medical Training Aids Learning
THURSDAY, Sept. 25, 2025 -- A student-led program in which medical students share their own personal stories with illness during a preclinical curriculum enhances learning...
Clinical Practice Guidelines Issued for Diabetes Distress
THURSDAY, Sept. 25, 2025 -- The first clinical practice guidelines on assessment and management of diabetes distress among adults were presented at the annual meeting of the...
Older Adults Can Regain Well-Being
THURSDAY, Sept. 25, 2025 -- Older adults can regain well-being, according to a study published online Sept. 24 in PLOS ONE. Mabel Ho, Ph.D., and Esme Fuller-Thomson, Ph.D...
More news resources
- FDA Medwatch Drug Alerts
- Daily MedNews
- News for Health Professionals
- New Drug Approvals
- New Drug Applications
- Drug Shortages
- Clinical Trial Results
- Generic Drug Approvals
Subscribe to our newsletter
Whatever your topic of interest, subscribe to our newsletters to get the best of Drugs.com in your inbox.