Advanced Biological Age Linked to Increased Risk for Incident Dementia
By Elana Gotkine HealthDay Reporter
FRIDAY, May 2, 2025 -- Advanced biological age (BA) may be a risk factor for incident dementia, according to a study published online April 30 in Neurology.
Yacong Bo, Ph.D., from The Third Affiliated Hospital of Zhengzhou University in China, and colleagues used data from the U.K. Biobank to examine the relationships of BA with incident dementia and explore underlying mechanisms. BA was evaluated using the Klemera-Doubal method biological age (KDM-BA) and PhenoAge algorithms. The apolipoprotein E (APOE) ε4 genotype and polygenic risk scores (PRSs) were used to assess the genetic risk for dementia.
The study included 280,918 participants. The researchers identified 4,770 cases of dementia recorded during a median follow-up of 13.58 years. Each standard deviation increase in KDM-BA and PhenoAge accelerations was associated with an increased incidence of dementia (hazard ratios, 1.14 and 1.15, respectively). The highest risk for dementia was seen for individuals with APOE ε4 and highest PhenoAge accelerations (hazard ratio, 4.20) compared with those with non-APOE ε4 and lowest PhenoAge accelerations, with a significant interaction effect. PRS did not have a significant modification effect on the association between BA accelerations and dementia, nor did APOE ε4 on the association between KDM-BA accelerations and dementia. The associations between BA accelerations and incident dementia were partially mediated by gray matter volume, cortical mean thickness, and cortical surface area, with the proportion-mediated percentage varying from 6.64 to 17.98 percent.
"Our findings suggested that advanced BA may contribute to changes in brain structures, thereby increasing susceptibility to dementia," the authors write.
Abstract/Full Text (subscription or payment may be required)
Disclaimer: Statistical data in medical articles provide general trends and do not pertain to individuals. Individual factors can vary greatly. Always seek personalized medical advice for individual healthcare decisions.
© 2025 HealthDay. All rights reserved.
Posted May 2025
Read this next
Myocardial Fibrosis Linked to Ventricular Arrhythmia in Male Endurance Athletes
TUESDAY, July 22, 2025 -- Myocardial fibrosis is independently associated with the onset of ventricular arrhythmia in male veteran endurance athletes, according to a study...
Risk for Dementia, Ischemic Stroke, Mortality Lower With GLP-1 Receptor Agonists in T2D, Obesity
TUESDAY, July 22, 2025 -- For adults with type 2 diabetes and obesity, glucagon-like peptide 1 receptor agonists (GLP-1 RAs) are associated with a lower risk for dementia, stroke...
Digital Model Based on Noninvasive Factors Shows Accuracy for Identifying IBD in Children
TUESDAY, July 22, 2025 -- A model based on noninvasive tests shows high accuracy as a digital tool for the rapid identification of children with inflammatory bowel disease (IBD)...
More news resources
- FDA Medwatch Drug Alerts
- Daily MedNews
- News for Health Professionals
- New Drug Approvals
- New Drug Applications
- Drug Shortages
- Clinical Trial Results
- Generic Drug Approvals
Subscribe to our newsletter
Whatever your topic of interest, subscribe to our newsletters to get the best of Drugs.com in your inbox.