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Pancreatin 4X

Generic name: pancreatinPAN-kree-a-tin ]
Brand names: Hi-Vegi-Lip, Pancreatin 4X
Drug class: Digestive enzymes

Medically reviewed by on Aug 9, 2023. Written by Cerner Multum.

What is pancreatin?

Pancreatin is a combination of digestive enzymes (proteins). These enzymes are normally produced by the pancreas and are important for digesting fats, proteins, and sugars.

Pancreatin is used to replace digestive enzymes when the body does not have enough of its own. Certain medical conditions can cause this lack of enzymes, such as cystic fibrosis, pancreatitis, pancreatic cancer, or pancreas surgery.

Pancreatin may also be used to treat a condition called steatorrhea (loose, fatty stools).

Pancreatin may also be used for purposes not listed in this medication guide.

Pancreatin side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Pancreatin 4X may cause serious side effects. Call your doctor at once if you have:

Common side effects of Pancreatin 4X may include:

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


You should not take pancreatin if you are allergic to pork proteins, or if you have a sudden onset of pancreatitis or worsening of a long-term problem with your pancreas.

Before taking this medicine

You should not take pancreatin if you are allergic to pork proteins, or if you have a sudden onset of pancreatitis or worsening of a long-term problem with your pancreas.

To make sure pancreatin is safe for you, tell your doctor if you have:

FDA pregnancy category C. It is not known whether pancreatin will harm an unborn baby. Do not use this medicine without a doctor's advice if you are pregnant.

It is not known whether pancreatin passes into breast milk or if it could harm a nursing baby. Do not use this medicine without a doctor's advice if you are breast-feeding a baby.

How should I take pancreatin?

Use exactly as directed on the label, or as prescribed by your doctor. Your doctor may occasionally change your dose to make sure you get the best results. Do not use in larger or smaller amounts or for longer than recommended.

Pancreatin should be taken with a meal or snack.

Take pancreatin with a full glass of water.

Do not hold the tablet in your mouth. The medicine may irritate the inside of your mouth.

Do not crush, chew, or break a pancreatin tablet. Swallow it whole.

To be sure this medicine is helping your condition, you may need frequent blood tests. You may not notice any change in your symptoms, but your blood work will help your doctor determine how long to treat you with pancreatin.

Call your doctor if your symptoms do not improve, or if they get worse while using pancreatin.

Pancreatin may be only part of a complete program of treatment that also includes a special diet. Follow the diet plan created for you by your doctor or nutrition counselor. Get familiar with the list of foods you must eat or avoid to help control your condition.

Use pancreatin regularly to get the most benefit. Get your prescription refilled before you run out of medicine completely. You may need to use this medicine for the rest of your life.

Store at room temperature away from moisture and heat.

If your doctor changes your brand, strength, or type of pancreatin, your dosage needs may change. Ask your pharmacist if you have any questions about the new kind of pancreatin you receive at the pharmacy.

What happens if I miss a dose?

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

Always take pancreatin with food.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while taking pancreatin?

Do not take any other digestive enzymes unless your doctor tells you to.

Avoid taking an antacid within 1 hour before or after you take pancreatin.

What other drugs will affect pancreatin?

Other drugs may interact with pancreatin, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using.

More about Pancreatin 4X (pancreatin)

Patient resources

Other brands

Pan-2400, Hi-Vegi-Lip

Related treatment guides

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.