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Aloxi (injection)

Generic Name: palonosetron (injection) (PAL oh NOE se tron)
Brand Name: Aloxi

Medically reviewed on May 7, 2018

What is palonosetron?

Palonosetron blocks the actions of chemicals in the body that can trigger nausea and vomiting.

Palonosetron is used in adults to prevent nausea and vomiting caused by surgery, or by receiving medicine to treat cancer (chemotherapy).

Palonosetron is used in children only to prevent nausea and vomiting caused by cancer medicine.

Palonosetron may also be used for purposes not listed in this medication guide.

Important Information

Before you receive palonosetron, tell your doctor about all your medical conditions or allergies, and all the medicines you are using. Also make sure your doctor knows if you are pregnant or breast-feeding.

Before taking this medicine

You should not be treated with palonosetron if you are allergic to it.

Tell your doctor if you have ever had an allergic reaction to a similar medicine for nausea or vomiting, such as dolasetron (Anzemet) or ondansetron (Zofran).

Tell your doctor if you are pregnant.

You should not breast-feed while using this medicine.

How is palonosetron given?

Palonosetron is given as an infusion into a vein. A healthcare provider will give you this injection.

Palonosetron is usually given 30 minutes before chemotherapy, or right before you are given anesthesia for surgery.

What happens if I miss a dose?

Because you will receive palonosetron in a clinical setting, you are not likely to miss a dose.

What happens if I overdose?

Since this medicine is given by a healthcare professional in a medical setting, an overdose is unlikely to occur.

What should I avoid while receiving palonosetron?

Follow your doctor's instructions about any restrictions on food, beverages, or activity.

Palonosetron side effects

Get emergency medical help if you have signs of an allergic reaction: hives; chest pain, difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • high levels of serotonin in the body--agitation, hallucinations, fever, fast heart rate, overactive reflexes, nausea, vomiting, diarrhea, loss of coordination, fainting.

Common side effects may include:

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

See also: Side effects (in more detail)

What other drugs will affect palonosetron?

Using palonosetron while you are using certain other medicines can cause high levels of serotonin to build up in your body, a condition called "serotonin syndrome," which can be fatal. Tell your doctor if you also use:

This list is not complete and many other drugs may affect palonosetron. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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