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In the US, Tolvaptan (tolvaptan systemic) is a member of the drug class vasopressin antagonists and is used to treat Euvolemic Hyponatremia and Hyponatremia.

US matches:



ATC (Anatomical Therapeutic Chemical Classification)


CAS registry number (Chemical Abstracts Service)


Chemical Formula


Molecular Weight


Therapeutic Categories

Diuretic agent

Treatment of heart failure

Treatment of hyponatremia

Vasopressin V2 receptor antagonist

Chemical Names

(±)-4'-[(7-chloro-2,3,4,5-tetrahydro-5-hydroxy-1H-1-benzazepin-1-yl)carbonyl]-o-tolu-m-toluidide (WHO)

(RS)-N-[4-(7-Chloro-5-hydroxy-2,3,4,5-tetrahydrobenzo[b]azepin-1-carbonyl)-3-metylphenyl]-2-metylbenzamide (IUPAC)

Benzamide, N-[4-[(7-chloro-2,3,4,5-tetrahydro-5-hydroxy-1H-1-benzazepin-1-yl)carbonyl]-3-metylphenyl]-2-metyl- (USAN)

Foreign Names

  • Tolvaptanum (Latin)
  • Tolvaptan (German)
  • Tolvaptan (French)
  • Tolvaptán (Spanish)

Generic Names

  • Tolvaptan (OS: USAN, JAN, BAN)
  • OPC-41061 (IS)
  • UNII-21G72T1950 (IS)

Brand Names

  • Jinarc
    Otsuka, Germany; Otsuka Pharmaceuticals Europe, United Kingdom
  • Samsca
    Korea Otsuka Pharmaceutical, South Korea; Otsuka, Canada; Otsuka, Germany; Otsuka, Denmark; Otsuka, Spain; Otsuka, Finland; Otsuka, France; Otsuka, Hong Kong; Otsuka, Netherlands; Otsuka, Portugal; Otsuka America Pharmaceuticals, United States; Otsuka Pharma Scandinavia, Sweden; Otsuka Pharmaceutical, Japan; Otsuka Pharmaceutical, Lithuania; Otsuka Pharmaceutical, Norway; Otsuka Pharmaceutical, Poland; Otsuka Pharmaceuticals Europe, United Kingdom; Otsuka-GB, Italy; Thai Otsuka, Thailand


BANBritish Approved Name
IUPACInternational Union of Pure and Applied Chemistry
ISInofficial Synonym
JANJapanese Accepted Name
OSOfficial Synonym
Rec.INNRecommended International Nonproprietary Name (World Health Organization)
USANUnited States Adopted Name
WHOWorld Health Organization

Further information on drug naming conventions: International Nonproprietary Names.

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Further information

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