Drug Interaction Report

Talk to your doctor before using promethazine together with donepezil. Medications like promethazine may reduce the effectiveness of donepezil. In addition, patients with Alzheimer's disease or other dementia may be more likely to experience nervous system side effects of promethazine such as drowsiness, confusion, and mental impairment. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Ask your doctor before using promethazine together with ethanol (alcohol). This can cause uncontrollable movements, agitation, seizures, severe dizziness or fainting, coma, very deep sleep, irregular heartbeats, and high or low body temperature. Use caution when driving, operating machinery, or performing other hazardous activities, these medicaions may cause dizziness or drowsiness. If you experience dizziness or drowsiness, avoid these activities. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.