Drug Interaction Report
1 potential interaction and/or warning found for the following 2 drugs:
- colistimethate
- givosiran
Interactions between your drugs
colistimethate givosiran
Applies to: colistimethate, givosiran
MONITOR: Increased adverse effects are possible when glycopeptide, polypeptide, or polymyxin antibiotics are administered concomitantly with other potentially nephrotoxic and neurotoxic drugs.
MANAGEMENT: If these drugs must be used together, renal function, auditory and vestibular function, and serum drug concentrations should be monitored.
References (3)
- (2001) "Product Information. Vancocin (vancomycin)." Lilly, Eli and Company
- Cerner Multum, Inc. "Australian Product Information."
- Dubrovskaya Y, Prasad N, Lee Y, Esaian D, Figueroa DA, Tam VH (2015) "Risk factors for nephrotoxicity onset associated with polymyxin B therapy." J Antimicrob Chemother, 70, p. 1903-7
Drug and food interactions
No alcohol/food interactions were found with the drugs in your list. However, this does not necessarily mean no food interactions exist. Always consult your healthcare provider.
Therapeutic duplication warnings
No duplication warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
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