Drug Interaction Report
21 potential interactions and/or warnings found for the following 11 drugs:
- Clomid (clomiphene)
- clomiphene
- atovaquone / proguanil
- doxycycline
- mefloquine
- chloroquine
- hydroxychloroquine
- pyrimethamine / sulfadoxine
- primaquine
- tafenoquine
- sulfadoxine
Interactions between your drugs
chloroquine primaquine
Applies to: chloroquine, primaquine
Using chloroquine together with primaquine can increase the risk of an irregular heart rhythm that may be serious and potentially life-threatening, although it is a rare side effect. You may be more susceptible if you have a heart condition called congenital long QT syndrome, other cardiac diseases, conduction abnormalities, or electrolyte disturbances (for example, magnesium or potassium loss due to severe or prolonged diarrhea or vomiting). Talk to your doctor if you have any questions or concerns. Your doctor may already be aware of the risks, but has determined that this is the best course of treatment for you and has taken appropriate precautions and is monitoring you closely for any potential complications. You should seek immediate medical attention if you develop sudden dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations during treatment with these medications, whether together or alone. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
chloroquine hydroxychloroquine
Applies to: chloroquine, hydroxychloroquine
Using chloroquine together with hydroxychloroquine can increase the risk of an irregular heart rhythm that may be serious and potentially life-threatening, although it is a rare side effect. You may be more susceptible if you have a heart condition called congenital long QT syndrome, other cardiac diseases, conduction abnormalities, or electrolyte disturbances (for example, magnesium or potassium loss due to severe or prolonged diarrhea or vomiting). Talk to your doctor if you have any questions or concerns. Your doctor may already be aware of the risks, but has determined that this is the best course of treatment for you and has taken appropriate precautions and is monitoring you closely for any potential complications. You should seek immediate medical attention if you develop sudden dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations during treatment with these medications, whether together or alone. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
mefloquine hydroxychloroquine
Applies to: mefloquine, hydroxychloroquine
Using hydroxychloroquine together with mefloquine can increase the risk of an irregular heart rhythm that may be serious and potentially life-threatening, although it is a rare side effect. You may be more susceptible if you have a heart condition called congenital long QT syndrome, other cardiac diseases, conduction abnormalities, or electrolyte disturbances (for example, magnesium or potassium loss due to severe or prolonged diarrhea or vomiting). Talk to your doctor if you have any questions or concerns. Your doctor may already be aware of the risks, but has determined that this is the best course of treatment for you and has taken appropriate precautions and is monitoring you closely for any potential complications. You should seek immediate medical attention if you develop sudden dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations during treatment with these medications, whether together or alone. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
primaquine hydroxychloroquine
Applies to: primaquine, hydroxychloroquine
Using hydroxychloroquine together with primaquine can increase the risk of an irregular heart rhythm that may be serious and potentially life-threatening, although it is a rare side effect. You may be more susceptible if you have a heart condition called congenital long QT syndrome, other cardiac diseases, conduction abnormalities, or electrolyte disturbances (for example, magnesium or potassium loss due to severe or prolonged diarrhea or vomiting). Talk to your doctor if you have any questions or concerns. Your doctor may already be aware of the risks, but has determined that this is the best course of treatment for you and has taken appropriate precautions and is monitoring you closely for any potential complications. You should seek immediate medical attention if you develop sudden dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations during treatment with these medications, whether together or alone. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
chloroquine mefloquine
Applies to: chloroquine, mefloquine
Using mefloquine together with chloroquine may increase the risk of convulsions and other heart problems. If mefloquine is used to treat severe malaria, mefloquine should not be given until 12 hours after the last dose of chloroquine. Contact your doctor if you condition changes or if you experience increased side effects. If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
mefloquine primaquine
Applies to: mefloquine, primaquine
Using mefloquine together with primaquine can increase the risk of irregular heart rhythm that may be serious and potentially life-threatening. You may be more susceptible if you have a heart condition called congenital long QT syndrome, other cardiac diseases, conduction abnormalities, or electrolyte disturbances (for example, magnesium or potassium loss due to severe or prolonged diarrhea or vomiting). Talk to your doctor if you have any questions or concerns. You should seek immediate medical attention if you develop sudden dizziness, lightheadedness, fainting, shortness of breath, slow heart rate, weak pulse, or heart palpitations during treatment. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
pyrimethamine sulfadoxine
Applies to: pyrimethamine / sulfadoxine, pyrimethamine / sulfadoxine, sulfadoxine
Using pyrimethamine together with sulfadoxine can increase your risk of anemias. Contact your doctor if you experience any changes in your blood test or if you feel weak or fatigued. You may need a dose adjustment or special test if you use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
pyrimethamine proguanil
Applies to: pyrimethamine / sulfadoxine, atovaquone / proguanil
Using pyrimethamine together with proguanil can increase the risk of side effects that affect your bone marrow function, resulting in low numbers of different types of blood cells. This can make you more likely to develop anemia, bleeding problems, or infections. Contact your doctor if you experience potential signs and symptoms of these conditions such as paleness of skin, fatigue, dizziness, fainting, unusual bleeding or bruising, fever, chills, sore throat, body aches, or other flu-like symptoms. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
No other interactions were found between your selected drugs. However, this does not necessarily mean no other interactions exist. Always consult your healthcare provider.
Drug and food interactions
chloroquine food
Applies to: chloroquine
You may want to limit your consumption of grapefruit or grapefruit juice during treatment with chloroquine. Grapefruit juice can significantly increase the blood levels and effects of chloroquine, which may result in an irregular heart rate or other conduction disturbances. Talk to your doctor if you have any questions or concerns. You should seek immediate medical attention if you develop sudden dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations during treatment with chloroquine. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
mefloquine food
Applies to: mefloquine
Food can enhance the levels of mefloquine in your body. Take mefloquine immediately after a meal. This will make it easier for your body to absorb the medication. Take each dose with a full glass, at least 8 ounces (240 mL) of water. For children or those who have difficulty swallowing, mefloquine can be crushed and mixed with water or sugar water. Talk to your healthcare provider if swallowing the tablets is difficult.
hydroxychloroquine food
Applies to: hydroxychloroquine
You may want to limit your consumption of grapefruit or grapefruit juice during treatment with hydroxychloroquine. Grapefruit juice can significantly increase the blood levels and effects of hydroxychloroquine, which may result in an irregular heart rate or other conduction disturbances. Talk to your doctor if you have any questions or concerns. You should seek immediate medical attention if you develop sudden dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations during treatment with hydroxychloroquine. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
atovaquone food
Applies to: atovaquone / proguanil
Food significantly enhances the absorption of atovaquone. You should take each dose of atovaquone at the same time each day with a meal or a milky drink. If you receive enteral nutrition (tube feeding), take atovaquone with your feeding. Taking it on an empty stomach may lead to inadequate blood levels and reduced effectiveness of the medication. Talk to your doctor if you have questions or have difficulty taking atovaquone with food.
tafenoquine food
Applies to: tafenoquine
Food helps with the absorption of tafenoquine into the blood stream. You should take this medication with food as directed.
doxycycline food
Applies to: doxycycline
Iron can bind to doxycycline in the gastrointestinal tract, which may prevent their absorption into the bloodstream and possibly reduce their effectiveness. To avoid or minimize the interaction, iron-containing medications and doxycycline should preferably be taken at least three to four hours apart in most cases. Talk to your doctor if you have any questions or concerns, or if you have trouble separating the dosing times. Your doctor may be able to prescribe alternatives that do not interact. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
doxycycline food
Applies to: doxycycline
Information for this minor interaction is available on the professional version.
Therapeutic duplication warnings
Therapeutic duplication is the use of more than one medicine from the same drug category or therapeutic class to treat the same condition. This can be intentional in cases where drugs with similar actions are used together for demonstrated therapeutic benefit. It can also be unintentional in cases where a patient has been treated by more than one doctor, or had prescriptions filled at more than one pharmacy, and can have potentially adverse consequences.
Anti-infectives
Therapeutic duplication
The recommended maximum number of medicines in the 'anti-infectives' category to be taken concurrently is usually three. Your list includes nine medicines belonging to the 'anti-infectives' category:
- atovaquone / proguanil
- doxycycline
- mefloquine
- chloroquine
- hydroxychloroquine
- pyrimethamine / sulfadoxine
- primaquine
- tafenoquine
- sulfadoxine
Note: In certain circumstances, the benefits of taking this combination of drugs may outweigh any risks. Always consult your healthcare provider before making changes to your medications or dosage.
Antiparasitic drugs
Therapeutic duplication
The recommended maximum number of medicines in the 'antiparasitic drugs' category to be taken concurrently is usually two. Your list includes eight medicines belonging to the 'antiparasitic drugs' category:
- atovaquone / proguanil
- doxycycline
- mefloquine
- chloroquine
- hydroxychloroquine
- pyrimethamine / sulfadoxine
- primaquine
- tafenoquine
Note: In certain circumstances, the benefits of taking this combination of drugs may outweigh any risks. Always consult your healthcare provider before making changes to your medications or dosage.
Antimalarials
Therapeutic duplication
The recommended maximum number of medicines in the 'antimalarials' category to be taken concurrently is usually one. Your list includes eight medicines belonging to the 'antimalarials' category:
- atovaquone / proguanil
- doxycycline
- mefloquine
- chloroquine
- hydroxychloroquine
- pyrimethamine / sulfadoxine
- primaquine
- tafenoquine
Note: In certain circumstances, the benefits of taking this combination of drugs may outweigh any risks. Always consult your healthcare provider before making changes to your medications or dosage.
Sulfonamides
Therapeutic duplication
The recommended maximum number of medicines in the 'sulfonamides' category to be taken concurrently is usually one. Your list includes two medicines belonging to the 'sulfonamides' category:
- pyrimethamine / sulfadoxine
- sulfadoxine
Note: In certain circumstances, the benefits of taking this combination of drugs may outweigh any risks. Always consult your healthcare provider before making changes to your medications or dosage.
Estrogen agonists-antagonists
Therapeutic duplication
The recommended maximum number of medicines in the 'estrogen agonists-antagonists' category to be taken concurrently is usually one. Your list includes two medicines belonging to the 'estrogen agonists-antagonists' category:
- Clomid (clomiphene)
- clomiphene
Note: In certain circumstances, the benefits of taking this combination of drugs may outweigh any risks. Always consult your healthcare provider before making changes to your medications or dosage.
Selective estrogen receptor modulators
Therapeutic duplication
The recommended maximum number of medicines in the 'selective estrogen receptor modulators' category to be taken concurrently is usually one. Your list includes two medicines belonging to the 'selective estrogen receptor modulators' category:
- Clomid (clomiphene)
- clomiphene
Note: In certain circumstances, the benefits of taking this combination of drugs may outweigh any risks. Always consult your healthcare provider before making changes to your medications or dosage.
Drug Interaction Classification
Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
No interaction information available. |
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Further information
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