Drug Interaction Report
1 drug interaction and 9 additional warnings found for the following 2 drugs:
- cevimeline
- trofinetide
Drug interactions
Moderate drug interactions
Moderate:cevimeline trofinetide
Applies to: cevimeline, trofinetide
Trofinetide may increase the blood levels and effects of cevimeline.
Talk to your doctor if you have any questions or concerns.
You may need more frequent monitoring to safely use both medications. Contact your doctor if your condition changes or you experience increased side effects.
It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Food/lifestyle interactions
No alcohol/food interactions were found with the drugs in your list. However, this does not necessarily mean no food interactions exist. Always consult your healthcare provider.
Disease interactions
9 potential interactionsApplies to: 9 conditions, including Asthma, Heart Attack, COPD, Angina, and Nephrolithiasis.
Angina
Major:cevimeline
Cevimeline has a major potential interaction with Angina.
Cevimeline may alter cardiac conduction and/or heart rate. Patients with significant cardiovascular disease may be unable to compensate for transient changes in hemodynamics or rhythm induced by cevimeline. Cevimeline should be used with caution and under close medical supervision in patients with a history of cardiovascular disease.
Asthma
Major:cevimeline
Cevimeline has a major potential interaction with Asthma.
The use of cevimeline is contraindicated in patients with uncontrolled asthma. Cevimeline can potentially increase airway resistance, bronchial smooth muscle tone, and bronchial secretions. This agent should be administered with caution and with close medical supervision in patients with controlled asthma, chronic bronchitis, or chronic obstructive pulmonary disease.
Cardiovascular Conditions and Disorders
Major:cevimeline
Cevimeline has a major potential interaction with Cardiovascular Conditions and Disorders.
Cevimeline may alter cardiac conduction and/or heart rate. Patients with significant cardiovascular disease may be unable to compensate for transient changes in hemodynamics or rhythm induced by cevimeline. Cevimeline should be used with caution and under close medical supervision in patients with a history of cardiovascular disease.
COPD
Major:cevimeline
Cevimeline has a major potential interaction with COPD.
The use of cevimeline is contraindicated in patients with uncontrolled asthma. Cevimeline can potentially increase airway resistance, bronchial smooth muscle tone, and bronchial secretions. This agent should be administered with caution and with close medical supervision in patients with controlled asthma, chronic bronchitis, or chronic obstructive pulmonary disease.
Gallstones
Moderate:cevimeline
Cevimeline has a moderate potential interaction with Gallstones.
Cevimeline should be administered with caution in patients with a history of cholelithiasis. Contractions of the gallbladder or biliary smooth muscle may precipitate complications such as cholecystitis, cholangitis and biliary obstruction.
Glaucoma, Narrow Angle
Major:cevimeline
Cevimeline has a major potential interaction with Glaucoma, Narrow Angle.
Cevimeline is contraindicated when miosis is undesirable, such in patients with narrow-angle (angle-closure) glaucoma or in acute iritis.
Heart Attack
Major:cevimeline
Cevimeline has a major potential interaction with Heart Attack.
Cevimeline may alter cardiac conduction and/or heart rate. Patients with significant cardiovascular disease may be unable to compensate for transient changes in hemodynamics or rhythm induced by cevimeline. Cevimeline should be used with caution and under close medical supervision in patients with a history of cardiovascular disease.
Nephrolithiasis
Moderate:cevimeline
Cevimeline has a moderate potential interaction with Nephrolithiasis.
Cevimeline should be administered with caution to patients with a history of nephrolithiasis. An increase in the ureteral smooth muscle tone may precipitate renal colic or ureteral reflux in patients with nephrolithiasis.
Uveitis
Major:cevimeline
Cevimeline has a major potential interaction with Uveitis.
Cevimeline is contraindicated when miosis is undesirable, such in patients with narrow-angle (angle-closure) glaucoma or in acute iritis.
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.