Drug Interaction Report
1 potential interaction and/or warning found for the following 2 drugs:
- berotralstat
- pitolisant
Interactions between your drugs
pitolisant berotralstat
Applies to: pitolisant, berotralstat
Consumer information for this interaction is not currently available.
GENERALLY AVOID: Coadministration with inducers of P-glycoprotein (P-gp) may significantly decrease the plasma concentrations and pharmacologic effects of berotralstat, a substrate of this efflux transporter. Clinical data evaluating this interaction are not available.
MANAGEMENT: Due to the potential for diminished pharmacologic effects of berotralstat, its concomitant use with P-gp inducers, including but not limited to rifampin and St. John's wort, should be avoided. Alternative therapeutic agents with less P-gp induction potential should be considered whenever possible.
Drug and food interactions
No alcohol/food interactions were found with the drugs in your list. However, this does not necessarily mean no food interactions exist. Always consult your healthcare provider.
Therapeutic duplication warnings
No duplication warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
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