Drug Interaction Report
1 potential interaction and/or warning found for the following 2 drugs:
- Cresemba (isavuconazonium)
- prednisone
Interactions between your drugs
predniSONE isavuconazonium
Applies to: prednisone, Cresemba (isavuconazonium)
MONITOR: Coadministration of isavuconazonium sulfate (prodrug of isavuconazole), a substrate as well as a moderate inhibitor of CYP450 3A4/5, with drugs that are both a substrate as well as inducer of CYP450 3A4/5 may result in decreased plasma concentrations of isavuconazole and increased plasma concentrations of the other drug. Isavuconazole may inhibit the metabolism of the coadministered drug while its own metabolism may be induced by the coadministered drug.
MANAGEMENT: Caution is advised if isavuconazonium sulfate is used concomitantly with drugs that are both a substrate and inducer of CYP450 3A4/5, particularly those with a narrow therapeutic range. Dosage adjustments as well as clinical and laboratory monitoring may be appropriate whenever these drugs are added to or withdrawn from combination therapy.
References (4)
- (2003) "Product Information. Emend (aprepitant)." Merck & Co., Inc
- Cerner Multum, Inc. "UK Summary of Product Characteristics."
- (2008) "Product Information. Emend for Injection (fosaprepitant)." Merck & Co., Inc
- (2015) "Product Information. Cresemba (isavuconazonium)." Astellas Pharma US, Inc
Drug and food interactions
No alcohol/food interactions were found with the drugs in your list. However, this does not necessarily mean no food interactions exist. Always consult your healthcare provider.
Therapeutic duplication warnings
No duplication warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
Report options
- Switch to consumer interaction data
- Email this report to a friend, doctor, or patient
- Ask questions, find answers
Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
See also:
AmBisome
Ambisome (amphotericin B) is used to treat serious, life-threatening fungal infections, including a ...
Sporanox
Sporanox (itraconazole) is used to treat fungal infections of the lungs, mouth, throat, toenails ...
Botox
Botox is used for cosmetic purposes and to treat overactive bladder symptoms, urinary incontinence ...
Noxafil
Noxafil prevents fungal infections in people with weak immune systems resulting from chemotherapy ...
Vfend
Vfend (voriconazole) is used to treat infections caused by yeast or other types of fungal ...
Amphotec
Amphotec is used for aspergillosis, invasive, candidemia, febrile neutropenia, histoplasmosis ...
Abelcet
Abelcet is used for aspergillosis, aspergilloma, aspergillosis, invasive, blastomycosis ...
Cancidas
Cancidas is used for aspergillosis, invasive, candidemia, esophageal candidiasis, febrile neutropenia
Tolsura
Tolsura is used for aspergillosis, invasive, blastomycosis, histoplasmosis
Learn more
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Check Interactions
To view an interaction report containing 4 (or more) medications, please sign in or create an account.
Save Interactions List
Sign in to your account to save this drug interaction list.