Drug Interaction Report
2 potential interactions and/or warnings found for the following 2 drugs:
- Namzaric (donepezil / memantine)
- opicapone
Interactions between your drugs
memantine opicapone
Applies to: Namzaric (donepezil / memantine), opicapone
Memantine may theoretically enhance the pharmacologic effects of dopaminergic agents. The clinical significance is unknown.
References (1)
- Cerner Multum, Inc. "UK Summary of Product Characteristics."
Drug and food interactions
opicapone food
Applies to: opicapone
ADJUST DOSING INTERVAL: Food may reduce the rate and extent of absorption of opicapone. When opicapone was administered following a moderate fat/moderate calorie meal, mean opicapone peak plasma concentration (Cmax) and systemic exposure (AUC) decreased by 62% and 31%, respectively, while the time to reach peak concentration (Tmax) was delayed by 4 hours.
MANAGEMENT: Patients should avoid eating 1 to 2 hours before and after taking opicapone.
References (2)
- Cerner Multum, Inc. "Australian Product Information."
- (2020) "Product Information. Ongentys (opicapone)." Neurocrine Biosciences, Inc.
Therapeutic duplication warnings
No duplication warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
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