Drug Interaction Report
2 potential interactions and/or warnings found for the following 2 drugs:
- arbutamine
- Pronestyl (procainamide)
Interactions between your drugs
procainamide arbutamine
Applies to: Pronestyl (procainamide), arbutamine
CONTRAINDICATED: Arbutamine may precipitate or exacerbate supraventricular or ventricular arrhythmias due to its sympathomimetic effects.
MANAGEMENT: The manufacturer recommends that arbutamine not be given concurrently with proarrhythmic drugs.
References (1)
- (2001) "Product Information. GenESA (arbutamine)." Gensia Inc
Drug and food interactions
procainamide food
Applies to: Pronestyl (procainamide)
Ethanol may increase the acetylation of procainamide. Subtherapeutic plasma levels of procainamide may result in some patients. Because the acetylated metabolite of procainamide also possesses antiarrhythmic properties, the clinical effects are unclear.
References (1)
- Olsen H, Morland J (1982) "Ethanol-induced increase in procainamide acetylation in man." Br J Clin Pharmacol, 13, p. 203-8
Therapeutic duplication warnings
No duplication warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
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