Drug Interaction Report

When use of sodium nitrite is required, the doctor should be told if you have been receiving treatment with tadalafil. Sodium nitrite can cause hypotension (low blood pressure), and the risk may be greater when combined with other medications that decrease blood pressure such as tadalafil. Excessively low blood pressure can lead to shock, collapse, coma, or even death. Your doctor will need to monitor you closely and possibly take extra precautions for you to safely use these medications together. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Tadalafil can lower blood pressure, and combining it with alcohol may further increase this effect. You may be more likely to experience symptoms such as dizziness, lightheadedness, fainting, flushing, headache, and heart palpitations. You should avoid or limit the use of alcohol to not more than 4 alcohol-containing drinks during a small period of time while being treated with tadalafil, and use caution when getting up from a sitting or lying position. You may also want to avoid drinking large amounts of grapefruit juice, since it may increase the blood levels and effects of tadalafil. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.