Drug Interaction Report
1 potential interaction and/or warning found for the following 2 drugs:
- pyrazinamide
- sulfinpyrazone
Interactions between your drugs
pyrazinamide sulfinpyrazone
Applies to: pyrazinamide, sulfinpyrazone
MONITOR: Pyrazinamide may antagonize the effects of uricosuric agents such as benzbromarone, probenecid, and sulfinpyrazone. The mechanism for this interaction has not been delineated.
MANAGEMENT: Caution is advised when pyrazinamide is used concomitantly with uricosuric agents. Dosage adjustments as well as clinical and laboratory monitoring for altered uricosuric efficacy should be considered. Some authorities recommend avoiding concomitant use of pyrazinamide and probenecid (AU).
References (2)
- Cerner Multum, Inc. "UK Summary of Product Characteristics."
- Agencia Española de Medicamentos y Productos Sanitarios Healthcare (2008) Centro de información online de medicamentos de la AEMPS - CIMA. https://cima.aemps.es/cima/publico/home.html
Drug and food/lifestyle interactions
No alcohol/food interactions were found with the drugs in your list. However, this does not necessarily mean no food interactions exist. Always consult your healthcare provider.
Therapeutic duplication warnings
No duplication warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
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