Drug Interaction Report

By reducing the acidity level in the stomach, medications like omeprazole may interfere with the absorption of sotorasib into the bloodstream and reduce its effectiveness. It is generally best to avoid using these medications together when possible. Some prescription and over-the-counter medications may also contain antacids or other agents that can neutralize acid. You should check the ingredients of all medications you take to see if they may contain antacids. Talk to your doctor or pharmacist if you have any questions or concerns. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

By reducing the acidity level in the stomach, medications like sodium bicarbonate may interfere with the absorption of sotorasib into the bloodstream and reduce its effectiveness. It is generally best to avoid using these medications together when possible. However, if you have no other alternatives for treatment, it is recommended that you take sotorasib 4 hours before or 10 hours after sodium bicarbonate to help minimize the impact of the interaction. Some prescription and over-the-counter medications may also contain antacids or other agents that can neutralize acid. You should check the ingredients of all medications you take to see if they may contain antacids. Talk to your doctor or pharmacist if you have any questions or concerns. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Information for this minor interaction is available on the professional version.