Drug Interaction Report
2 potential interactions and/or warnings found for the following 2 drugs:
- Konvomep (omeprazole / sodium bicarbonate)
- linaclotide
Interactions between your drugs
omeprazole linaclotide
Applies to: Konvomep (omeprazole / sodium bicarbonate), linaclotide
The concomitant use of linaclotide with proton pump inhibitors, laxatives, or nonsteroidal anti-inflammatory drugs may increase the risk of diarrhea. The clinical significance is unknown.
References (1)
- EMEA. European Medicines Agency (2007) EPARs. European Union Public Assessment Reports. http://www.ema.europa.eu/ema/index.jsp?curl=pages/includes/medicines/medicines_landingpage.jsp&mid
Drug and food interactions
linaclotide food
Applies to: linaclotide
ADJUST DOSING INTERVAL: Administration of linaclotide in the fed condition resulted in more gastrointestinal side effects and more frequent and looser stools, than when it was administered under fasting conditions.
MANAGEMENT: It is recommended to take linaclotide 30 minutes before a meal.
References (2)
- EMEA. European Medicines Agency (2007) EPARs. European Union Public Assessment Reports. http://www.ema.europa.eu/ema/index.jsp?curl=pages/includes/medicines/medicines_landingpage.jsp&mid
- (2012) "Product Information. Linzess (linaclotide)." Forest Pharmaceuticals
Therapeutic duplication warnings
No duplication warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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