Drug Interaction Report

Using oral rilpivirine together with omeprazole is not recommended. By reducing the acidity level in the stomach, omeprazole can decrease the absorption and blood levels of oral rilpivirine and make the medication less effective against HIV. Talk to a healthcare provider if you have any questions or concerns. Your doctor or pharmacist may be able to recommend alternatives that do not interact (or interact to a lesser extent) if you require treatment for stomach acid or ulcer while you are being treated with oral rilpivirine. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

By reducing the acidity level in the stomach, sodium bicarbonate can decrease the absorption and blood levels of rilpivirine and make the medication less effective against HIV. To minimize the risk of interaction, sodium bicarbonate should be taken at least 2 hours before or 4 hours after you take rilpivirine. Talk to your doctor or pharmacist if you have questions on how to take this or other medications you are prescribed. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Food significantly increases the absorption of rilpivirine. You should take each dose of rilpivirine with a meal. Taking it on an empty stomach may lead to inadequate blood levels and reduced effectiveness of the medication. Grapefruit juice can also increase the absorption of rilpivirine and should preferably be avoided.