Drug Interaction Report
2 potential interactions and/or warnings found for the following 2 drugs:
- Konvomep (omeprazole / sodium bicarbonate)
- trovafloxacin
Interactions between your drugs
sodium bicarbonate trovafloxacin
Applies to: Konvomep (omeprazole / sodium bicarbonate), trovafloxacin
GENERALLY AVOID: Urinary alkalinizers such as citrates may decrease the solubility of fluoroquinolones in the urine and increase the risk of crystalluria.
MANAGEMENT: Concomitant use should generally be avoided. Patients receiving this combination should be monitored for signs of renal toxicity and crystalluria.
References (1)
- (2002) "Product Information. Cipro (ciprofloxacin)." Bayer
omeprazole trovafloxacin
Applies to: Konvomep (omeprazole / sodium bicarbonate), trovafloxacin
Minor increases in trovafloxacin AUC and peak serum concentrations have occurred when trovafloxacin was administered with omeprazole. The mechanism has not been described. The manufacturer does not consider this pharmacokinetic drug interaction to be of clinical importance.
References (2)
- (2001) "Product Information. Trovan (trovafloxacin)." Pfizer U.S. Pharmaceuticals
- Teng R, Dogolo LC, Willavize SA, Friedman HL, Vincent J (1997) "Effect of Maalox and omeprazole on the bioavailability of trovafloxacin." J Antimicrob Chemother, 39 Suppl B, p. 93-7
Drug and food interactions
No alcohol/food interactions were found with the drugs in your list. However, this does not necessarily mean no food interactions exist. Always consult your healthcare provider.
Therapeutic duplication warnings
No duplication warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
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