Drug Interaction Report

Using saquinavir together with omeprazole may increase the effects of saquinavir. Contact your doctor if you experience fever, sore throat, and headache with a severe blistering, peeling, and red skin rash, increased urination or extreme thirst, easy bruising or bleeding, signs of a new infection, such as fever or chills, cough, or flu symptoms, or nausea, stomach pain, low fever, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes). If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Food can enhance the levels of saquinavir in your body. Saquinavir should be taken with meals or within 2 hours after eating. This will make it easier for your body to absorb the medication. Grapefruit can raise the levels of saquinavir in your body. Discuss the use of grapefruit products with your doctor. Do not increase or decrease the amount of grapefruit products in your diet without first talking to your doctor.