Drug Interaction Report

Consumer information for this interaction is not currently available.

ADJUST DOSING INTERVAL: Products containing aluminum, calcium, magnesium and other polyvalent cations such as antacids or vitamin with mineral supplements are likely to interfere with the gastrointestinal absorption of oral bisphosphonates. For example, the bioavailability of tiludronate has been shown to decrease 80% during simultaneous administration with calcium, and 60% when aluminum- or magnesium-containing antacids were administered one hour before tiludronate.

MANAGEMENT: Antacids or other oral medications containing aluminum, calcium, magnesium and other polyvalent cations should be administered at least 2 hours before or 2 hours after the bisphosphonate dose.

Food significantly decreases the levels of tiludronate. Tiludronate should be administered on an empty stomach with 6 to 8 ounces of plain water at least 2 hours before or 2 hours after food. This will make it easier for your body to absorb the medication.