Drug Interaction Report
1 potential interaction and/or warning found for the following 2 drugs:
- measles virus vaccine / mumps virus vaccine / rubella virus vaccine / varicella virus vaccine
- valacyclovir
Interactions between your drugs
varicella virus vaccine valACYclovir
Applies to: measles virus vaccine / mumps virus vaccine / rubella virus vaccine / varicella virus vaccine, valacyclovir
GENERALLY AVOID: Concomitant use of live, attenuated varicella virus vaccine or zoster vaccine with acyclovir, famciclovir, or valacyclovir may result in diminished immunologic response to the vaccine. Although clinical data are lacking, theoretical concern exists that antiviral activity against the vaccine strain may prevent a sufficient degree of replication to occur in order to induce a protective immune response. Acyclovir, specifically, has demonstrated activity against the Oka strain of live, attenuated varicella-zoster virus used in the vaccines.
MANAGEMENT: Acyclovir, famciclovir, and valacyclovir should not be used for at least 24 hours before administration of live, attenuated varicella virus vaccine or zoster vaccine. In addition, these antiviral agents should generally be avoided for 14 days after vaccination.
References (2)
- (2017) "Product Information. Zovirax (acyclovir)." Mylan Pharmaceuticals Inc
- US Centers for Disease Control and Prevention (CDC) (2017) Recommended immunization schedule for adults aged 19 years or older, United States, 2017 https://www.cdc.gov/vaccines/schedules/downloads/adult/adult-combined-schedule-bw.pdf
Drug and food interactions
No alcohol/food interactions were found with the drugs in your list. However, this does not necessarily mean no food interactions exist. Always consult your healthcare provider.
Therapeutic duplication warnings
No duplication warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
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