Drug Interaction Report

Ceritinib may increase the blood levels and effects of levobupivacaine. Before you receive levobupivacaine, let your doctor know if you have been using ceritinib. You may need a dose adjustment or closer monitoring by your doctor to safely use both medications. Let your doctor know if you experience dizziness, lightheadedness, anxiety, restlessness, tremors, twitching, numbness and tingling of the mouth and lips, metallic taste, ringing in the ears or blurred vision, , as these may be early symptoms of excessive levobupivacaine levels. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Do not consume grapefruit or grapefruit juice during treatment with ceritinib unless directed otherwise by your doctor. Grapefruit juice can increase the blood levels of ceritinib to dangerous levels, increasing the risk of an irregular heart rhythm that may be serious. Other, more common side effects such as diarrhea, nausea, vomiting, abdominal pain, and hyperglycemia (high blood sugar) may also increase. You should seek immediate medical attention if you develop sudden dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations during treatment with ceritinib. Food may also increase the blood levels of ceritinib. Therefore, you should take ceritinib on an empty stomach, meaning no food should be eaten for at least two hours before or after taking ceritinib. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.