Drug Interaction Report
2 potential interactions and/or warnings found for the following 2 drugs:
- Amersham Indium (111In) Oxine (indium oxyquinoline in-111)
- ceftibuten
Interactions between your drugs
ceftibuten indium oxyquinoline In-111
Applies to: ceftibuten, Amersham Indium (111In) Oxine (indium oxyquinoline in-111)
MONITOR: Certain medications may decrease chemotaxis and cause false-negative results with Indium In-111-labeled leukocyte studies.
MANAGEMENT: Clinicians should be aware of possible diagnostic interference in patients who are on long-term antibiotic treatment, corticosteroids, interleukin-2, parenteral nutrition, or high doses or supratherapeutic concentrations of lidocaine or procainamide.
References (1)
- (2022) "Product Information. Indium Oxyquinoline In-111 (indium oxyquinoline In-111)." GE Healthcare
Drug and food interactions
ceftibuten food
Applies to: ceftibuten
ADJUST DOSING INTERVAL: Food reduces the oral absorption and bioavailability of ceftibuten. According to the product labeling, administration of ceftibuten oral suspension with a high-fat breakfast decreased the mean peak plasma concentration (Cmax) and area under the concentration-time curve (AUC) by 26% and 17%, respectively. Administration of ceftibuten capsules with a standardized breakfast decreased the mean peak plasma concentration (Cmax) and area under the concentration-time curve (AUC) by 18% and 8%, respectively.
MANAGEMENT: To ensure maximal oral absorption, ceftibuten oral suspension should be taken at least two hours before or one hour after a meal.
References (1)
- (2001) "Product Information. Cedax (ceftibuten)." Schering-Plough
Therapeutic duplication warnings
No duplication warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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