Povidone K90
Excipient (pharmacologically inactive substance)
What is it?
Povidone (polyvinylpyrrolidone, PVP) is used in the pharmaceutical industry as a synthetic polymer vehicle for dispersing and suspending drugs. It has multiple uses, including as a binder for tablets and capsules, a film former for ophthalmic solutions, to aid in flavoring liquids and chewable tablets, and as an adhesive for transdermal systems.[1]
Povidone has the molecular formula of (C6H9NO)n and appears as a white to slightly off-white powder. Povidone formulations are widely used in the pharmaceutical industry due to their ability to dissolve in both water and oil solvents. The k number refers to the mean molecular weight of the povidone. Povidones with higher K-values (i.e., k90) are not usually given by injection due to their high molecular weights. The higher molecular weights prevent excretion by the kidneys and lead to accumulation in the body. The best-known example of povidone formulations is povidone-iodine, an important disinfectant.[2]
[1] Dave RH. Overview of pharmaceutical excipients used in tablets and capsules. Drug Topics (online). Advanstar. 10/24/2008 http://drugtopics.modernmedicine.com/drugtopics/Top+News/Overview-of-pharmaceutical-excipients-used-in-tabl/ArticleStandard/Article/detail/561047. Accessed 08/19/2011
[2] Folttman H, Quadir A. Excipent Update. Polyvinylpyrrolidone (PVP) - one of the mosy widely used excipients in pharmaceuricals: an overview. Drug Delivery Technology. Vol 8;6:22-7. Accessed April 9, 2012. http://www.pharma-ingredients.basf.com/Documents/ENP/Review%20Articles/DDT-June-2008.pdf
Top Medications with this excipient
- Clonazepam 1 mg (Teva Pharmaceuticals USA)
- Clonazepam 0.5 mg (Teva Pharmaceuticals USA)
- Clonazepam 2 mg (Teva Pharmaceuticals USA)
- Clozapine 100 mg (Teva Pharmaceuticals USA)
- Diclofenac Sodium Extended-Release 100 mg (Teva Pharmaceuticals USA)
- Metformin Hydrochloride 500 mg (Aurobindo Pharma)
- Metformin Hydrochloride 1000 mg (Heritage Pharmaceuticals, Inc.)
- Metformin Hydrochloride 500 mg (Heritage Pharmaceuticals, Inc.)
- Methocarbamol 750 mg (Camber Pharmaceuticals, Inc.)
- Methocarbamol 500 mg (Camber Pharmaceuticals, Inc.)
- Naproxen Delayed Release 500 mg (Teva Pharmaceuticals USA)
- Pantoprazole Sodium Delayed Release 40 mg (ESI Lederle Generics)
- Penicillin V Potassium 500 mg (Greenstone Limited)
- Penicillin V Potassium 250 mg (Greenstone Limited)
- Protonix 40 mg (Wyeth)
- Protonix 20 mg (Wyeth-Ayerst Laboratories)
- Tramadol Hydrochloride Extended Release 100 mg (Par Pharmaceutical Inc.)
- Tramadol Hydrochloride Extended Release 200 mg (Par Pharmaceutical Inc.)
- Valacyclovir Hydrochloride 1 gram (Aurobindo Pharma)
- Valacyclovir Hydrochloride 500 mg (Aurobindo Pharma)
