Povidone K90
Excipient (pharmacologically inactive substance)
What is it?
Povidone (polyvinylpyrrolidone, PVP) is used in the pharmaceutical industry as a synthetic polymer vehicle for dispersing and suspending drugs. It has multiple uses, including as a binder for tablets and capsules, a film former for ophthalmic solutions, to aid in flavoring liquids and chewable tablets, and as an adhesive for transdermal systems.[1]
Povidone has the molecular formula of (C6H9NO)n and appears as a white to slightly off-white powder. Povidone formulations are widely used in the pharmaceutical industry due to their ability to dissolve in both water and oil solvents. The k number refers to the mean molecular weight of the povidone. Povidones with higher K-values (i.e., k90) are not usually given by injection due to their high molecular weights. The higher molecular weights prevent excretion by the kidneys and lead to accumulation in the body. The best-known example of povidone formulations is povidone-iodine, an important disinfectant.[2]
[1] Dave RH. Overview of pharmaceutical excipients used in tablets and capsules. Drug Topics (online). Advanstar. 10/24/2008 http://drugtopics.modernmedicine.com/drugtopics/Top+News/Overview-of-pharmaceutical-excipients-used-in-tabl/ArticleStandard/Article/detail/561047. Accessed 08/19/2011
[2] Folttman H, Quadir A. Excipent Update. Polyvinylpyrrolidone (PVP) - one of the mosy widely used excipients in pharmaceuricals: an overview. Drug Delivery Technology. Vol 8;6:22-7. Accessed April 9, 2012. http://www.pharma-ingredients.basf.com/Documents/ENP/Review%20Articles/DDT-June-2008.pdf
Top Medications with this excipient
- CellCept 250 mg
- Cellcept 500 mg
- Clonazepam 2 mg
- ConRx Allergy Sinus acetaminophen 325 mg / chlorpheniramine maleate 2 mg / phenylephrine hydrochloride 5 mg
- ConRx Cold acetaminophen 325 mg / dextromethorphan hydrobromide 10 mg / guaifenesin 200 mg / phenylephrine hydrochloride 5 mg
- EC-Naprosyn 500 mg
- Ergoloid Mesylates 1 mg
- Metformin Hydrochloride 500 mg
- Metformin Hydrochloride 500 mg
- Metformin Hydrochloride 1000 mg
- Metformin Hydrochloride 850 mg
- Metformin Hydrochloride 850 mg
- Methocarbamol 500 mg
- Methocarbamol 750 mg
- Naprosyn 250 mg
- Pantoprazole Sodium Delayed Release 40 mg
- Penicillin V Potassium 500 mg
- Tracleer 62.5 mg
- Valacyclovir Hydrochloride 500 mg
- Valacyclovir Hydrochloride 500 mg
