Excipient (pharmacologically inactive substance)
What is it?
Povidone (polyvinylpyrrolidone, PVP) is used in the pharmaceutical industry as a synthetic polymer vehicle for dispersing and suspending drugs. It has multiple uses, including as a binder for tablets and capsules, a film former for ophthalmic solutions, to aid in flavoring liquids and chewable tablets, and as an adhesive for transdermal systems.
Povidone k30 has the molecular formula of (C6H9NO)n and appears as a white to slightly off-white powder. Povidone formulations are widely used in the pharmaceutical industry due to their ability to dissolve in both water and oil solvents. The k number refers to the mean molecular weight of the povidone. Povidones with higher K-values (i.e., k90) are not usually given by injection due to their high molecular weights. The higher molecular weights prevent excretion by the kidneys and lead to accumulation in the body. The best-known example of povidone formulations is povidone-iodine, an important disinfectant.
 Dave RH. Overview of pharmaceutical excipients used in tablets and capsules. Drug Topics (online). Advanstar. 10/24/2008 http://drugtopics.modernmedicine.com/drugtopics/Top+News/Overview-of-pharmaceutical-excipients-used-in-tabl/ArticleStandard/Article/detail/561047. Accessed 08/19/2011
 Folttman H, Quadir A. Excipent Update. Polyvinylpyrrolidone (PVP) - one of the mosy widely used excipients in pharmaceuricals: an overview. Drug Delivery Technology. Vol 8;6:22-7. Accessed April 9, 2012. http://www.pharma-ingredients.basf.com/Documents/ENP/Review%20Articles/DDT-June-2008.pdf
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Top Medications with this excipient
- Acetaminophen and Hydrocodone Bitartrate 325 mg / 7.5 mg
- Acetaminophen and Hydrocodone Bitartrate 325 mg / 5 mg
- Acetaminophen and Hydrocodone Bitartrate 325 mg / 10 mg
- Acetaminophen and Oxycodone Hydrochloride 325 mg / 10 mg
- Acetaminophen and Oxycodone Hydrochloride 325 mg / 7.5 mg
- Baclofen 10 mg
- Buprenorphine Hydrochloride (Sublingual) 8 mg
- Carisoprodol 350 mg
- Ciprofloxacin Hydrochloride 500 mg
- Meloxicam 15 mg
- Metformin Hydrochloride 500 mg
- Mirtazapine 15 mg
- Omeprazole Delayed Release 20 mg
- Q-Pap 325 mg
- Q-Pap Extra Strength 500 mg
- Quetiapine Fumarate 50 mg
- Quetiapine Fumarate 200 mg
- Quetiapine Fumarate 25 mg
- Quetiapine Fumarate 100 mg
- Tramadol Hydrochloride Extended Release 150 mg