Ethylcellulose (100 MPa.s)
Excipient (pharmacologically inactive substance)
What is it?
Ethylcellulose is a free-flowing, white to light tan powder used in the pharmaceutical and food manufacturing industries. It is prepared from wood pulp or cotton by treatment with alkali and ethylation of the alkali cellulose with ethyl chloride. Ethylcellulose is used in pharmaceutical industry as a coating agent, flavoring fixative, tablet binder and filler, and as a viscosity-increasing agent. Ethyl cellulose is also used in the food industry as an emulsifier.[1] [2]
There is very limited data detailing possible side effects of ethylcellulose; however it is included in the FDA generally regarded as safe (GRAS) Database of Substances (SCOGS) Reviews.[3]
[1] Dave RH. Overview of pharmaceutical excipients used in tablets and capsules. Drug Topics (online). Advanstar. 10/24/2008 http://drugtopics.modernmedicine.com/drugtopics/Top+News/Overview-of-pharmaceutical-excipients-used-in-tabl/ArticleStandard/Article/detail/561047. Accessed 08/19/2011
[2] Food and Agriculture Organization of the United States. Prepared at the 26th JECFA (1982), published in FNP 25 ( 1982) and FNP. 52 (1992). Accessed March 31, 2012. Ethylcellulose. http://www.fao.org/ag/agn/jecfa-additives/specs/Monograph1/Additive-178.pdf
[3] FDA’s SCOGS database; Ethylcellulose; SCOGS-Report Number: 25; http://www.accessdata.fda.gov/scripts/fcn/fcnDetailNavigation.cfm?rpt=scogsListing&id=365 Accessed March 31, http://www.accessdata.fda.gov/scripts/fcn/fcnDetailNavigation.cfm?rpt=scogsListing&id=119
Top Medications with this excipient
- Clarinex-D 24 Hour 5 mg / 240 mg (Schering-Plough Corporation)
- Copegus 200 mg (Roche Laboratories)
- Dextroamphetamine Sulfate Extended Release 15 mg (CorePharma, LLC)
- Dextroamphetamine Sulfate Extended Release 5 mg (CorePharma, LLC)
- Dextroamphetamine Sulfate Extended Release 10 mg (CorePharma, LLC)
- Effexor XR 37.5 mg (Wyeth-Ayerst Laboratories)
- Effexor XR 150 mg (Wyeth-Ayerst Laboratories)
- Effexor XR 75 mg (Wyeth-Ayerst Laboratories)
- Lamictal ODT 25 mg (GlaxoSmithKline)
- Micro-K 8 mEq (Ther-RX)
- Micro-K 10 10 mEq (Ther-RX)
- Namenda XR 21 mg (Forest Pharmaceuticals, Inc.)
- Namenda XR 28 mg (Forest Pharmaceuticals, Inc.)
- Namenda XR 7 mg (Forest Pharmaceuticals, Inc.)
- Namenda XR 14 mg (Forest Pharmaceuticals, Inc.)
- Potassium Chloride Extended-Release 20 mEq (1500 mg) (Watson Laboratories, Inc.)
- Prenatal Plus Prenatal Vit 27 mg Fe Fumarate 1 mg (Major Pharmaceuticals Inc.)
- Venlafaxine Hydrochloride Extended-Release 37.5 mg (Orchid Healthcare)
- Venlafaxine Hydrochloride Extended-Release 150 mg (Orchid Healthcare)
- Venlafaxine Hydrochloride Extended-Release 75 mg (Orchid Healthcare)
