Ethylcellulose (100 MPa.s)
Excipient (pharmacologically inactive substance)
What is it?
Ethylcellulose is a free-flowing, white to light tan powder used in the pharmaceutical and food manufacturing industries. It is prepared from wood pulp or cotton by treatment with alkali and ethylation of the alkali cellulose with ethyl chloride. Ethylcellulose is used in pharmaceutical industry as a coating agent, flavoring fixative, tablet binder and filler, and as a viscosity-increasing agent. Ethyl cellulose is also used in the food industry as an emulsifier.[1] [2]
There is very limited data detailing possible side effects of ethylcellulose; however it is included in the FDA generally regarded as safe (GRAS) Database of Substances (SCOGS) Reviews.[3]
[1] Dave RH. Overview of pharmaceutical excipients used in tablets and capsules. Drug Topics (online). Advanstar. 10/24/2008 http://drugtopics.modernmedicine.com/drugtopics/Top+News/Overview-of-pharmaceutical-excipients-used-in-tabl/ArticleStandard/Article/detail/561047. Accessed 08/19/2011
[2] Food and Agriculture Organization of the United States. Prepared at the 26th JECFA (1982), published in FNP 25 ( 1982) and FNP. 52 (1992). Accessed March 31, 2012. Ethylcellulose. http://www.fao.org/ag/agn/jecfa-additives/specs/Monograph1/Additive-178.pdf
[3] FDA’s SCOGS database; Ethylcellulose; SCOGS-Report Number: 25; http://www.accessdata.fda.gov/scripts/fcn/fcnDetailNavigation.cfm?rpt=scogsListing&id=365 Accessed March 31, http://www.accessdata.fda.gov/scripts/fcn/fcnDetailNavigation.cfm?rpt=scogsListing&id=119
Top Medications with this excipient
- Aplenzin 348 mg (Sanofi-Aventis)
- Aplenzin 522 mg (Sanofi-Aventis)
- Carbamazepine 200 mg (Teva Pharmaceuticals USA)
- Carbamazepine (chewable) 100 mg (Teva Pharmaceuticals USA)
- Clarinex-D 24 Hour 5 mg / 240 mg (Schering-Plough Corporation)
- Copegus 200 mg (Roche Laboratories)
- Dextroamphetamine Sulfate Extended Release 15 mg (CorePharma, LLC)
- Dextroamphetamine Sulfate Extended Release 10 mg (CorePharma, LLC)
- Effexor XR 75 mg (Wyeth-Ayerst Laboratories)
- Effexor XR 150 mg (Wyeth-Ayerst Laboratories)
- Effexor XR 37.5 mg (Wyeth-Ayerst Laboratories)
- Epitol 200 mg (Teva Pharmaceuticals USA)
- Lamictal ODT 25 mg (GlaxoSmithKline)
- Lamictal ODT 100 mg (GlaxoSmithKline)
- Lamictal ODT 50 mg (GlaxoSmithKline)
- Namenda XR 28 mg (Forest Pharmaceuticals, Inc.)
- Namenda XR 14 mg (Forest Pharmaceuticals, Inc.)
- Potassium Chloride Extended-Release 20 mEq (1500 mg) (Watson Laboratories, Inc.)
- Prenatal Plus Prenatal Vit 27 mg Fe Fumarate 1 mg (Major Pharmaceuticals Inc.)
- Uroxatral 10 mg (Sanofi-Aventis)
