Inrebic and Alcohol/Food Interactions
There is 1 alcohol/food/lifestyle interaction with Inrebic (fedratinib).
Fedratinib Food
Moderate Food Interaction
Grapefruit juice can increase the blood levels of fedratinib. This may increase the risk of serious side effects such as Wernicke's encephalopathy, a potentially fatal condition of the brain associated with thiamine (vitamin B1) deficiency; low blood cell counts, which can lead to anemia, bleeding, and infections; severe diarrhea, nausea, and vomiting; problems in the liver or pancreas; and development of other cancers. You should avoid the consumption of grapefruit and grapefruit juice during treatment with fedratinib. You may take the medication with or without food, but taking it with a high-fat meal may help reduce nausea and vomiting. Talk to your doctor or pharmacist if you have questions on how to take this or other medications you are prescribed. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
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Inrebic drug interactions
There are 560 drug interactions with Inrebic (fedratinib).
Inrebic disease interactions
There are 9 disease interactions with Inrebic (fedratinib) which include:
- severe hepatic impairment
- thiamine deficiency
- Fedratinib-gastrointestinal toxicity
- cardiovascular risk
- malignancy
- thrombosis
- renal impairment
- Fedratinib-cytopenias
- Fedratinib-pancreatitis
More about Inrebic (fedratinib)
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- Drug class: multikinase inhibitors
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Related treatment guides
Drug Interaction Classification
Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
No interaction information available. |
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Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.