Emflaza and Alcohol/Food Interactions
There are 2 alcohol/food/lifestyle interactions with Emflaza (deflazacort).
Deflazacort Food
Moderate Food Interaction
Do not take deflazacort with grapefruit juice. Grapefruit juice may increase the blood levels of the active component of deflazacort. This may increase the risk and/or severity of side effects such as swelling, weight gain, electrolyte abnormalities, high blood pressure, high blood glucose, muscle weakness, depression, mood swings, acne, thinning skin, stretch marks, easy bruising, bone density loss, cataracts, glaucoma, menstrual irregularities, excessive growth of facial or body hair, and abnormal distribution of body fat, especially in the face, neck, back, and waist. Other side effects that may occur include decreased ability to fight infections, increased risk of developing infections, and inadequate response to stress such as infection, surgery, trauma, or a severe asthma attack. Children may experience a reduced growth rate during chronic use. Talk to your doctor if you have any questions or concerns. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Deflazacort High Blood Pressure (Hypertension)
Moderate Potential Hazard, Moderate plausibility
corticosteroids - fluid retention
Corticosteroids may cause hypernatremia, hypokalemia, fluid retention, and elevation in blood pressure. Large doses of any corticosteroid can demonstrate these effects, particularly if given for longer periods. Therapy with corticosteroids should be administered cautiously in patients with preexisting fluid retention, hypertension, congestive heart failure, and/or renal dysfunction. Dietary sodium restriction and potassium supplementation may be advisable.
References
- (2001) "Product Information. Hydeltrasol (prednisolone)." Merck & Co., Inc
- (2001) "Product Information. Deltasone (prednisone)." Pharmacia and Upjohn
- (2001) "Product Information. Decadron (dexamethasone)." Merck & Co., Inc
- (2001) "Product Information. Hydrocortone (hydrocortisone)." Merck & Co., Inc
- (2001) "Product Information. Medrol (methylprednisolone)." Pharmacia and Upjohn
- (2001) "Product Information. Florinef Acetate (fludrocortisone)." Bristol-Myers Squibb
- (2001) "Product Information. Cortone Acetate (cortisone)." Merck & Co., Inc
- (2001) "Product Information. Kenalog (triamcinolone)." Bristol-Myers Squibb
- (2001) "Product Information. Celestone (betamethasone)." Schering Corporation
- (2021) "Product Information. Emflaza (deflazacort)." PTC Therapeutics, Inc., SUPPL-5
- (2023) "Product Information. Agamree (vamorolone)." Santhera Pharmaceuticals (US)
Emflaza drug interactions
There are 537 drug interactions with Emflaza (deflazacort).
Emflaza disease interactions
There are 18 disease interactions with Emflaza (deflazacort) which include:
- (+) tuberculin test
- depression/psychoses
- diabetes
- electrolyte imbalance
- fluid retention
- GI perforation
- hyperadrenocorticalism
- hypothyroidism
- MI
- myopathy
- ocular herpes simplex
- ocular toxicities
- osteoporosis
- PUD
- strongyloidiasis
- thromboembolism
- hepatic impairment
- infections
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Drug Interaction Classification
Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.