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Drug Interactions between typhoid vaccine, live and vaccinia immune globulin

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Moderate

typhoid vaccine, live vaccinia immune globulin

Applies to: typhoid vaccine, live and vaccinia immune globulin

ADJUST DOSING INTERVAL: Administration of immunoglobulin preparations with or shortly before or after live vaccines may impair the immune response to the live vaccine(s). Injected live, attenuated virus vaccines such as measles/mumps/rubella (MMR), measles/mumps/rubella/varicella (MMRV) and varicella may be affected by circulating antibodies present in immunoglobulin therapy or other blood products. The passive transfer of the antibodies present in immunoglobulin preparations may interfere with the immune response to the live vaccine(s), hence reducing their efficacy. There appears to be minimal to no interaction between immunoglobulin preparations or blood products and yellow fever vaccine, live oral vaccines (e.g., rotavirus vaccine, oral typhoid vaccine), live attenuated influenza vaccines and the Bacille Calmette-Guerin (BCG) vaccine. Data on the immunogenicity and safety of dengue vaccine or cholera vaccine (live, attenuated) after the administration of immunoglobulin preparations is not available.

MANAGEMENT: Immunization with live vaccines should be deferred until approximately 6 months after administration of vaccinia immune globulin intravenous (VIGIV). If such vaccinations are given shortly before or after VIGIV therapy, a revaccination may be necessary. An additional dose of live measles, mumps, or rubella vaccine is usually not needed if the vaccine was administered at least two weeks prior to immune globulin administration. Local immunization guidelines and prescribing information for specific vaccines should be consulted for further recommendations.

References (11)
  1. (1993) "Interference of immune globulin with measles and rubella immunization." Eur J Pediatr, 152, p. 536
  2. CDC. Centers for Disease Control and Prevention/ (1993) "Recommendations of the advisory committtee on immunization practices (ACIP): use of vaccines and immune globulins in persons with altered immunocompetence." MMWR Morb Mortal Wkly Rep, 42(RR-04), p. 1-18
  3. Department of Health. National Health Service (2019) Immunisation Against Infectious Disease - "The Green Book". Chapter 6: Contraindications and special considerations. https://assets.publishing.service.gov.uk/government/uploads/system/uploads/attachment_data/file/655225/Greenbook_chapter_6.pdf
  4. (2023) "Product Information. Vaxchora (cholera vaccine, live)." Patientric Ltd
  5. (2024) "Product Information. Vaxchora (cholera vaccine, live)." Emergent Travel Health, Inc
  6. Advisory Committee on Immunization Practices: Centers for Disease Control and Prevention General Best Practice Guidelines for Immunization: Timing and Spacing of Immunobiologics https://www.cdc.gov/vaccines/hcp/acip-recs/general-recs/timing.html
  7. Clucas L, Crawford N, Danchin M, Greenway A Live-attenuated vaccines in patients receiving regular red blood cell transfusions https://mvec.mcri.edu.au/references/live-attenuated-vaccines-in-patients-receiving-regular-red-blood-cell-transfusions/
  8. Melbourne Vaccine Education Centre Live-attenuated vaccines and immunoglobulins or blood products https://mvec.mcri.edu.au/references/live-attenuated-vaccines-and-immunoglobulins-or-blood-products/
  9. Australian Government. Department of Health and Aged Care Australian Immunisation Handbook: Vaccination for people who have recently received normal human immunoglobulin and other blood products https://immunisationhandbook.health.gov.au/contents/vaccination-for-special-risk-groups/vaccination-for-people-who-ha
  10. Australian Government. Department of Health and Aged Care Australian Immunisation Handbook: Tuberculosis https://immunisationhandbook.health.gov.au/contents/vaccine-preventable-diseases/tuberculosis
  11. Australian Government. Department of Health and Aged Care Australian Immunisation Handbook: Varicella (chickenpox) https://immunisationhandbook.health.gov.au/contents/vaccine-preventable-diseases/varicella-chickenpox

Drug and food interactions

No alcohol/food interactions were found. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

See also

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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