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Drug Interactions between Theocon Elixir and Zemuron

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Moderate

oxtriphylline rocuronium

Applies to: Theocon Elixir (guaifenesin / oxtriphylline) and Zemuron (rocuronium)

MONITOR: Methylxanthines may antagonize the effects of neuromuscular blockers. The mechanism is unknown. In patients stabilized on aminophylline, resistance to pancuronium has been reported.

MANAGEMENT: The patient should be monitored for adequate neuromuscular blockade and the dosage adjusted, if necessary.

References

  1. Daller JA, Erstad B, Rosado L, Otto C, Putnam CW "Aminophylline antagonizes the neuromuscular blockade of pancuronium but not vecuronium." Crit Care Med 19 (1991): 983-5
  2. Doll DC, Rosenberg H "Antagonism of neuromuscular blockage by theophylline." Anesth Analg 58 (1979): 139-40
  3. Azar I, Kumar D, Betcher AM "Resistance to pancuronium in an asthmatic patient treated with aminophylline and steroids." Can Anaesth Soc J 29 (1982): 280-2

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Drug and food interactions

No alcohol/food interactions were found. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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