Can you take Sorafenib with Sotorasib?
1 drug interaction and 6 additional warnings found for the following 2 drugs:
- sorafenib
- sotorasib
Drug interactions
Moderate drug interactions
Moderate:
SORAfenib sotorasib
Applies to: sorafenib and sotorasib
Sotorasib may reduce the blood levels of SORAfenib in some patients, which may make the medication less effective. Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Food/lifestyle interactions
Moderate food/lifestyle interactions
Moderate:
SORAfenib Food/Lifestyle
Applies to: sorafenib
You may experience reduced absorption of SORAfenib in the presence of food. Take SORAfenib on an empty stomach 1 hour before or 2 hours after a meal unless otherwise directed by your doctor. This will make it easier for your body to absorb the medication.
Minor food/lifestyle interactions
Minor:
sotorasib Food/Lifestyle
Applies to: sotorasib
Information for this minor interaction is available on the professional version.
Disease interactions
4 potential interactions Applies to: 4 conditions, including Liver Disease, Interstitial Lung Disease, Renal Dysfunction, and Pulmonary Impairment.
Interstitial Lung Disease
Moderate:
sorafenib
SORAfenib has a moderate potential interaction with Interstitial Lung Disease.
The use of certain multikinase inhibitors has been associated with pulmonary toxicity. Serious cases of interstitial lung disease (ILD), including fatal cases and interstitial pneumonitis or pulmonary fibrosis have been reported. Caution is recommended when using these agents in patients with a history of interstitial pneumonitis or pulmonary fibrosis or those patients presenting with acute onset of new or progressive unexplained pulmonary symptoms such as dyspnea, cough, and fever pending diagnostic evaluation. If ILD is confirmed, these agents should be permanently discontinued and appropriate measures should be instituted. Treatment should be immediately withheld in patients diagnosed with ILD/pneumonitis and permanently discontinued if no other potential causes of ILD/pneumonitis have been identified.
Liver Disease
Moderate:
sotorasib
Sotorasib has a moderate potential interaction with Liver Disease.
The effects of severe renal impairment or moderate to severe hepatic impairment on the pharmacokinetics of sotorasib have not been studied.
Pulmonary Impairment
Moderate:
sorafenib
SORAfenib has a moderate potential interaction with Pulmonary Impairment.
The use of certain multikinase inhibitors has been associated with pulmonary toxicity. Serious cases of interstitial lung disease (ILD), including fatal cases and interstitial pneumonitis or pulmonary fibrosis have been reported. Caution is recommended when using these agents in patients with a history of interstitial pneumonitis or pulmonary fibrosis or those patients presenting with acute onset of new or progressive unexplained pulmonary symptoms such as dyspnea, cough, and fever pending diagnostic evaluation. If ILD is confirmed, these agents should be permanently discontinued and appropriate measures should be instituted. Treatment should be immediately withheld in patients diagnosed with ILD/pneumonitis and permanently discontinued if no other potential causes of ILD/pneumonitis have been identified.
Renal Dysfunction
Moderate:
sotorasib
Sotorasib has a moderate potential interaction with Renal Dysfunction.
The effects of severe renal impairment or moderate to severe hepatic impairment on the pharmacokinetics of sotorasib have not been studied.
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More resources
sorafenib
A total of 451 drugs are known to interact with sorafenib.
- Sorafenib is in the following drug classes: multikinase inhibitors, VEGF/VEGFR inhibitors.
- Sorafenib is used to treat the following conditions:
sotorasib
A total of 535 drugs are known to interact with sotorasib.
- Sotorasib is in the drug class miscellaneous antineoplastics.
- Sotorasib is used to treat the following conditions:
Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.