Drug Interactions between SMZ-TMP DS and Vitamin B12
This report displays the potential drug interactions for the following 2 drugs:
- SMZ-TMP DS (sulfamethoxazole/trimethoprim)
- Vitamin B12 (cyanocobalamin)
Interactions between your drugs
No interactions were found between SMZ-TMP DS and Vitamin B12. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.
SMZ-TMP DS
A total of 432 drugs are known to interact with SMZ-TMP DS.
- Smz-tmp ds is in the drug class sulfonamides.
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Smz-tmp ds is used to treat the following conditions:
- Bacterial Infection
- Bacterial Skin Infection
- Bronchitis
- Diverticulitis
- Epiglottitis
- Granuloma Inguinale
- Infection Prophylaxis
- Kidney Infections
- Melioidosis
- Meningitis
- Middle Ear Infections
- Nocardiosis
- Pneumocystis Pneumonia
- Pneumocystis Pneumonia Prophylaxis
- Pneumonia
- Prevention of Bladder infection
- Prostatitis
- Shigellosis
- Sinusitis
- Toxoplasmosis
- Toxoplasmosis, Prophylaxis
- Traveler's Diarrhea
- Upper Respiratory Tract Infection
- Urinary Tract Infection
Vitamin B12
A total of 15 drugs are known to interact with Vitamin B12.
- Vitamin b12 is in the drug class vitamins.
- Vitamin b12 is used to treat the following conditions:
Drug and food interactions
sulfamethoxazole food
Applies to: SMZ-TMP DS (sulfamethoxazole / trimethoprim)
MONITOR: Two cases have been reported in which patients on sulfamethoxazole-trimethoprim therapy, after consuming beer, reported flushing, heart palpitations, dyspnea, headache, and nausea (disulfiram - alcohol type reactions). First-generation sulfonylureas have been reported to cause facial flushing when administered with alcohol by inhibiting acetaldehyde dehydrogenase and subsequently causing acetaldehyde accumulation. Since sulfamethoxazole is chemically related to first-generation sulfonylureas, a disulfiram-like reaction with products containing sulfamethoxazole is theoretically possible. However, pharmacokinetic/pharmacodynamic data are lacking and in addition, the two reported cases cannot be clearly attributed to the concomitant use of sulfamethoxazole-trimethoprim and alcohol.
MANAGEMENT: Patients should be alerted to the potential for this interaction and although the risk for this interaction is minimal, caution is recommended while taking sulfamethoxazole-trimethoprim concomitantly with alcohol.
References
- Heelon MW, White M (1998) "Disulfiram-cotrimoxazole reaction." Pharmacotherapy, 18, p. 869-70
- Mergenhagen KA, Wattengel BA, Skelly MK, Clark CM, Russo TA (2020) "Fact versus fiction: a review of the evidence behind alcohol and antibiotic interactions." Antimicrob Agents Chemother, 64, e02167-19
Therapeutic duplication warnings
No warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
See also
Drug Interaction Classification
Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
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