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Drug Interactions between silodosin and tolazoline

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Moderate

tolazoline silodosin

Applies to: tolazoline and silodosin

GENERALLY AVOID: Additive pharmacodynamic effects may be expected when relatively selective alpha-1A adrenoreceptor antagonists are coadministered with other alpha-blockers. Clinical data have not been reported, but there may be an increased risk and/or severity of adverse effects related to blockade of alpha-1 adrenergic receptors in the peripheral vasculature such as postural hypotension, dizziness, headache, syncope, priapism, and nasal congestion. These effects have occurred with alpha-1A adrenoreceptor antagonists even when given alone for the treatment of benign prostatic hyperplasia, despite relative selectivity for the 1A subtype of alpha-1 adrenoreceptors located in prostatic and bladder tissues.

MANAGEMENT: The use of relatively selective alpha-1A adrenoreceptor antagonists in combination with other alpha-blockers should be avoided.

References (2)
  1. (2001) "Product Information. Flomax (tamsulosin)." Boehringer-Ingelheim
  2. (2008) "Product Information. Rapaflo (silodosin)." Watson Pharmaceuticals

Drug and food interactions

Moderate

silodosin food

Applies to: silodosin

ADJUST DOSING INTERVAL: Food may reduce the oral bioavailability of silodosin. The effect of a moderate-fat, moderate-calorie meal on silodosin pharmacokinetics was variable and decreased silodosin maximum plasma concentration (Cmax) by approximately 18% to 43% and systemic exposure (AUC) by 4% to 49% across three different studies. The maximum effect of food (i.e., coadministration with a high-fat, high-calorie meal) on the pharmacokinetics of silodosin was not evaluated. Safety and efficacy clinical trials for silodosin were always conducted in the presence of food intake.

MANAGEMENT: Patients should be instructed to take silodosin with a meal to reduce the risk of adverse events.

References (1)
  1. (2008) "Product Information. Rapaflo (silodosin)." Watson Pharmaceuticals

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

See also

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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