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Drug Interactions between Septocaine and tamsulosin

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Moderate

EPINEPHrine tamsulosin

Applies to: Septocaine (articaine / epinephrine) and tamsulosin

MONITOR: Theoretically, the pharmacologic effects of agents that act through agonism at the alpha receptor may be antagonized by those that act via antagonism at the same receptor, and vice versa. Alpha-1 agonists and alpha agonists with beta-agonist effects exert opposing effects on vascular tone and blood pressure than alpha-1 antagonists. Some of these agents act on both alpha-1 and alpha-2 receptors, though they may have a stronger affinity for one or the other. The severity of the interaction may also be influenced by the degree of systemic absorption of each agent.

MANAGEMENT: Monitoring for diminished effects on blood pressure and vasoconstriction is recommended if an alpha-agonist (e.g., epinephrine, norepinephrine, ephedrine, metaraminol) is coadministered with an alpha-antagonist (e.g., phentolamine, phenoxybenzamine, terazosin). If the concomitant alpha agonist being used also acts on beta receptors, the effects of unopposed beta stimulation should also be considered.

References

  1. (2002) "Product Information. Intropin (dopamine)." DuPont Pharmaceuticals
  2. (2022) "Product Information. EPHEDrine Sulfate (ePHEDrine)." Akorn Inc
  3. (2016) "Product Information. Akovaz (ephedrine)." Eclat Pharmaceuticals
  4. (2016) "Product Information. Adrenaclick Two-Pack (epinephrine)." Amedra Pharmaceuticals LLC
  5. (2016) "Product Information. Auvi-Q (epinephrine)." sanofi-aventis
  6. (2016) "Product Information. EpiPen (epinephrine)." Dey Laboratories
  7. (2016) "Product Information. Adrenalin (epinephrine)." A-S Medication Solutions
  8. (2016) "Product Information. Epinephrine (epinephrine)." Physicians Total Care
  9. (2022) "Product Information. Anapen (adrenaline (epinephrine))." Link Medical Products Pty Ltd T/A Link Pharmaceuticals, 2.4
  10. (2023) "Product Information. Epinephrine (EPINEPHrine)." International Medication Systems, Limited
  11. (2023) "Product Information. Epinephrine (EPINEPHrine)." BPI Labs LLC, SUPPL-10
View all 11 references

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Drug and food interactions

Moderate

tamsulosin food

Applies to: tamsulosin

ADJUST DOSING INTERVAL: Food may delay the gastrointestinal absorption of tamsulosin. The time to maximum plasma concentration (Tmax) is reached by 4 to 5 hours under fasted conditions and by 6 to 7 hours when tamsulosin is administered with food. The delay in Tmax has the desirable effect of smoothing the tamsulosin plasma concentration profile, thereby reducing fluctuation of the plasma peak and trough concentrations with multiple dosing. Food may also affect the extent of absorption of tamsulosin. It has been reported that taking tamsulosin under fasted conditions results in a 30% increase in bioavailability (AUC) and 40% to 70% increase in peak plasma concentration (Cmax) compared to fed conditions. The effects of food on the pharmacokinetics of tamsulosin are consistent regardless of whether tamsulosin is taken with a light meal or a high-fat meal.

MANAGEMENT: To ensure uniformity of absorption, tamsulosin should be administered approximately one-half hour following the same meal each day.

References

  1. (2001) "Product Information. Flomax (tamsulosin)." Boehringer-Ingelheim

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Moderate

EPINEPHrine food

Applies to: Septocaine (articaine / epinephrine)

MONITOR: Coadministration of two or more sympathomimetic agents may increase the risk of adverse effects such as nervousness, irritability, and increased heart rate. Central nervous system (CNS) stimulants, particularly amphetamines, can potentiate the adrenergic response to vasopressors and other sympathomimetic agents. Additive increases in blood pressure and heart rate may occur due to enhanced peripheral sympathetic activity.

MANAGEMENT: Caution is advised if two or more sympathomimetic agents are coadministered. Pulse and blood pressure should be closely monitored.

References

  1. Rosenblatt JE, Lake CR, van Kammen DP, Ziegler MG, Bunney WE Jr (1979) "Interactions of amphetamine, pimozide, and lithium on plasma norepineophrine and dopamine-beta-hydroxylase in schizophrenic patients." Psychiatry Res, 1, p. 45-52
  2. Cavanaugh JH, Griffith JD, Oates JA (1970) "Effect of amphetamine on the pressor response to tyramine: formation of p-hydroxynorephedrine from amphetamine in man." Clin Pharmacol Ther, 11, p. 656
  3. (2001) "Product Information. Adderall (amphetamine-dextroamphetamine)." Shire Richwood Pharmaceutical Company Inc
  4. (2001) "Product Information. Tenuate (diethylpropion)." Aventis Pharmaceuticals
  5. (2001) "Product Information. Sanorex (mazindol)." Novartis Pharmaceuticals
  6. (2001) "Product Information. Focalin (dexmethylphenidate)." Mikart Inc
  7. (2002) "Product Information. Strattera (atomoxetine)." Lilly, Eli and Company
View all 7 references

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Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

See also

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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