Can you take Robafen DM Clear with Tetrabenazine?
1 drug interaction and 13 additional warnings found for the following 2 drugs:
- Robafen DM Clear (dextromethorphan/guaifenesin)
- tetrabenazine
Drug interactions
Moderate drug interactions
Moderate:
dextromethorphan tetrabenazine
Applies to: Robafen DM Clear (dextromethorphan / guaifenesin) and tetrabenazine
Using dextromethorphan together with tetrabenazine may increase side effects such as dizziness, drowsiness, confusion, and difficulty concentrating. Some people, especially the elderly, may also experience impairment in thinking, judgment, and motor coordination. You should avoid or limit the use of alcohol while being treated with these medications. Also avoid activities requiring mental alertness such as driving or operating hazardous machinery until you know how the medications affect you. Talk to your doctor if you have any questions or concerns. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Food/lifestyle interactions
Moderate food/lifestyle interactions
Moderate:
dextromethorphan Food/Lifestyle
Applies to: Robafen DM Clear (dextromethorphan / guaifenesin)
Alcohol can increase the nervous system side effects of dextromethorphan such as dizziness, drowsiness, and difficulty concentrating. Some people may also experience impairment in thinking and judgment. You should avoid or limit the use of alcohol while being treated with dextromethorphan. Do not use more than the recommended dose of dextromethorphan, and avoid activities requiring mental alertness such as driving or operating hazardous machinery until you know how the medication affects you. Talk to your doctor or pharmacist if you have any questions or concerns.
Moderate:
tetrabenazine Food/Lifestyle
Applies to: tetrabenazine
Alcohol can increase the nervous system side effects of tetrabenazine such as dizziness, drowsiness, and difficulty concentrating. Some people may also experience impairment in thinking and judgment. You should avoid or limit the use of alcohol while being treated with tetrabenazine. Do not use more than the recommended dose of tetrabenazine, and avoid activities requiring mental alertness such as driving or operating hazardous machinery until you know how the medication affects you. Talk to your doctor or pharmacist if you have any questions or concerns.
Disease interactions
11 potential interactions Applies to: 10 conditions, including Depression, Osteoporosis, Arrhythmia, Breast Cancer, and Hypotension.
Arrhythmia
Major:
tetrabenazine
Tetrabenazine has a major potential interaction with Arrhythmia.
Tetrabenazine can cause an increase in the corrected QT interval. QT prolongation can lead to the development of ventricular arrhythmias. The use of tetrabenazine should be avoided in patients with congenital long QT syndrome and in patients with a history of arrhythmias.
Breast Cancer
Moderate:
tetrabenazine
Tetrabenazine has a moderate potential interaction with Breast Cancer.
Tetrabenazine can elevate serum prolactin concentrations. This should be considered when therapy will be prescribed in patients with previously detected breast cancer. Additionally, chronic increase in serum prolactin has been associated with low levels of estrogen and increase risk of osteoporosis. If there is suspicion of hyperprolactinemia, appropriate laboratory testing is advised and treatment discontinuation should be considered.
Depression
Major:
tetrabenazine
Tetrabenazine has a major potential interaction with Depression.
The use of tetrabenazine is contraindicated in patients with untreated or uncontrolled depression. Tetrabenazine can increase the risk of depression and suicidal thoughts and behavior.
Dysphagia
Moderate:
tetrabenazine
Tetrabenazine has a moderate potential interaction with Dysphagia.
Tetrabenazine reduces dopaminergic transmission and can be associated with esophageal dysmotility and dysphagia. Caution should be exercised when used in patients with conditions that predispose to dysphagia. Special caution is advised in patients with Huntington's disease as dysphagia is a common symptom and it could lead to aspiration pneumonia.
Huntington's Disease
Major:
tetrabenazine
Tetrabenazine has a major potential interaction with Huntington's Disease.
Patients with Huntington disease are prone to depression. Tetrabenazine can increase the risk of depression and suicidal thoughts and should be used with caution in patients with Huntington's disease. The benefits and risks of treatment should be considered before starting therapy, and patients should be under close observation for emergence or worsening of depression symptoms. The family and caregivers should also be informed of this risk and should be instructed to report any changes in behavior or any concerns to the treating physician.
Moderate:
tetrabenazine
Tetrabenazine has a moderate potential interaction with Huntington's Disease.
Tetrabenazine reduces dopaminergic transmission and can be associated with esophageal dysmotility and dysphagia. Caution should be exercised when used in patients with conditions that predispose to dysphagia. Special caution is advised in patients with Huntington's disease as dysphagia is a common symptom and it could lead to aspiration pneumonia.
Hyperprolactinemia
Moderate:
tetrabenazine
Tetrabenazine has a moderate potential interaction with Hyperprolactinemia.
Tetrabenazine can elevate serum prolactin concentrations. This should be considered when therapy will be prescribed in patients with previously detected breast cancer. Additionally, chronic increase in serum prolactin has been associated with low levels of estrogen and increase risk of osteoporosis. If there is suspicion of hyperprolactinemia, appropriate laboratory testing is advised and treatment discontinuation should be considered.
Hypotension
Moderate:
tetrabenazine
Tetrabenazine has a moderate potential interaction with Hypotension.
Tetrabenazine can induce postural dizziness and syncope and should be used with caution in patients who are vulnerable to hypotension.
Liver Disease
Major:
tetrabenazine
Tetrabenazine has a major potential interaction with Liver Disease.
The use of tetrabenazine is contraindicated in patients with hepatic impairment. The safety and efficacy of exposure to the drug and other metabolites are unknown and it is not possible to adjust the dosage in hepatic impairment to ensure safe use.
Osteoporosis
Moderate:
tetrabenazine
Tetrabenazine has a moderate potential interaction with Osteoporosis.
Tetrabenazine can elevate serum prolactin concentrations. This should be considered when therapy will be prescribed in patients with previously detected breast cancer. Additionally, chronic increase in serum prolactin has been associated with low levels of estrogen and increase risk of osteoporosis. If there is suspicion of hyperprolactinemia, appropriate laboratory testing is advised and treatment discontinuation should be considered.
Syncope
Moderate:
tetrabenazine
Tetrabenazine has a moderate potential interaction with Syncope.
Tetrabenazine can induce postural dizziness and syncope and should be used with caution in patients who are vulnerable to hypotension.
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Robafen DM Clear
A total of 375 drugs are known to interact with Robafen DM Clear.
- Robafen dm clear is in the drug class upper respiratory combinations.
- Robafen dm clear is used to treat the following conditions:
tetrabenazine
A total of 567 drugs are known to interact with tetrabenazine.
- Tetrabenazine is in the drug class VMAT2 inhibitors.
-
Tetrabenazine is used to treat the following conditions:
- Huntington's Disease
- Tardive Dyskinesia (off-label)
Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.