Can you take Reserpine with Vasoxyl?
1 drug interaction and 10 additional warnings found for the following 2 drugs:
- reserpine
- Vasoxyl (methoxamine)
Drug interactions
Moderate drug interactions
Moderate:
reserpine methoxamine
Applies to: reserpine and Vasoxyl (methoxamine)
Using reserpine together with methoxamine may cause an increase in blood pressure and other cardiovascular side effects.
Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring to safely use both medications.
It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Food/lifestyle interactions
Moderate food/lifestyle interactions
Moderate:
reserpine Alcohol (Ethanol)
Applies to: reserpine
Ethanol and reserpine may have additive effects in lowering your blood pressure.
You may experience headache, dizziness, lightheadedness, fainting, or changes in pulse or heart rate, especially when treatment is started, the dose is changed, or treatment is restarted.
Tell your doctor promptly if these symptoms occur and seek urgent medical help if you faint or have severe dizziness.
Avoid driving or operating hazardous machinery until you know how the medications affect you, and use caution when getting up from a sitting or lying position.
It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Moderate:
methoxamine Caffeine
Applies to: Vasoxyl (methoxamine)
Both methoxamine and caffeine can increase blood pressure and heart rate, and combining them may enhance these effects.
Talk to your doctor before using these medications, especially if you have a history of high blood pressure or heart disease. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications.
Contact your doctor if your condition changes or you experience increased side effects.
It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Disease interactions
8 potential interactions Applies to: 8 conditions, including Depression, Inflammatory Bowel Disease, Peptic Ulcer, Gallstones, and Fluid Retention.
Acidosis
Moderate:
Vasoxyl
The methoxamine in Vasoxyl has a moderate potential interaction with Acidosis.
Acidosis, hypoxia, and hypercapnia may reduce the effectiveness of sympathomimetic amines in raising blood pressure. These conditions should be corrected before initiating therapy with sympathomimetic amines, if possible. Monitoring the patients acid-base balance, carbon dioxide levels, and oxygen saturation is recommended.
Dehydration
Major:
Vasoxyl
The methoxamine in Vasoxyl has a major potential interaction with Dehydration.
The use of sympathomimetic amines has been infrequently associated with significant hypotension especially in dehydrated patients secondary to the drug's beta-2 mediated vasodilation. Hypovolemia should be corrected, if possible, before administering sympathomimetic amines. Blood pressure and ECG should be monitored at regular intervals. Monitoring of cardiac output and pulmonary wedge pressure may also be desired.
Depression
Major:
reserpine
Reserpine has a major potential interaction with Depression.
The use of rauwolfia alkaloids is contraindicated in patients with a history of mental depression, especially suicidal tendencies. Rauwolfia alkaloids depletes catecholamine and serotonin stores.
Fluid Retention
Moderate:
reserpine
Reserpine has a moderate potential interaction with Fluid Retention.
Peripheral- acting antiadrenergic agents can cause peripheral edema. Therapy with peripheral- acting antiadrenergic agents should be administered cautiously in patients adversely affected by sodium and water retention.
Gallstones
Moderate:
reserpine
Reserpine has a moderate potential interaction with Gallstones.
Rauwolfia alkaloids increase gastrointestinal motility and secretion and can precipitate biliary colic in patients with gallstones. Therapy with rauwolfia alkaloids should be administered cautiously in patients with a history of gallstones.
Inflammatory Bowel Disease
Major:
reserpine
Reserpine has a major potential interaction with Inflammatory Bowel Disease.
The use of rauwolfia alkaloids is contraindicated in patients with active peptic ulcer or ulcerative colitis. Since rauwolfia alkaloids increase gastrointestinal motility and secretion, these conditions may be aggravated. Therapy with rauwolfia alkaloids should be administered cautiously in patients with a history of peptic ulcer or ulcerative colitis because of the risk of reactivation.
Peptic Ulcer
Major:
reserpine
Reserpine has a major potential interaction with Peptic Ulcer.
The use of rauwolfia alkaloids is contraindicated in patients with active peptic ulcer or ulcerative colitis. Since rauwolfia alkaloids increase gastrointestinal motility and secretion, these conditions may be aggravated. Therapy with rauwolfia alkaloids should be administered cautiously in patients with a history of peptic ulcer or ulcerative colitis because of the risk of reactivation.
Renal Dysfunction
Moderate:
reserpine
Reserpine has a moderate potential interaction with Renal Dysfunction.
In general, lowering the blood pressure may cause some decrease in renal function. Therefore, rauwolfia alkaloids should be used with caution in patients with renal impairment, since these patients may adjust poorly to the hypotensive effects of these agents.
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More resources
reserpine
A total of 329 drugs are known to interact with reserpine.
- Reserpine is in the drug class antiadrenergic agents, peripherally acting.
- Reserpine is used to treat the following conditions:
Vasoxyl
A total of 161 drugs are known to interact with Vasoxyl.
- Vasoxyl is in the drug class vasopressors.
Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.