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Drug Interactions between procainamide and trimethoprim

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Moderate

procainamide trimethoprim

Applies to: procainamide and trimethoprim

MONITOR: Trimethoprim may decrease the renal secretion of procainamide. Serum procainamide levels may be increased.

MANAGEMENT: Serum procainamide and NAPA levels should be checked during therapy, and procainamide dosage should be decreased, if necessary. Patients should be advised to promptly notify their physician if they experience drowsiness, dizziness, syncope, confusion, tremor, or palpitations.

References (3)
  1. Kosoglou T, Rocci M, Vlasses P (1988) "Trimethoprim alters the disposition of procainamide and N-acetylprocainamide." Clin Pharmacol Ther, 44, p. 467-77
  2. Harron D, Brogden R (1990) "Acecaindie (N-acetylprocainamide)." Drugs, 39, p. 720-40
  3. Vlasses P, Kosoglou T, Chase S, et al. (1989) "Trimethoprim inhibition of the renal clearance of procainamide and N-acetylprocainamide." Arch Intern Med, 149, p. 1350-3

Drug and food interactions

Minor

procainamide food

Applies to: procainamide

Ethanol may increase the acetylation of procainamide. Subtherapeutic plasma levels of procainamide may result in some patients. Because the acetylated metabolite of procainamide also possesses antiarrhythmic properties, the clinical effects are unclear.

References (1)
  1. Olsen H, Morland J (1982) "Ethanol-induced increase in procainamide acetylation in man." Br J Clin Pharmacol, 13, p. 203-8

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

See also

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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