Skip to main content

Drug Interactions between probenecid and Vabomere

This report displays the potential drug interactions for the following 2 drugs:

Edit list (add/remove drugs)

Interactions between your drugs

Moderate

probenecid meropenem

Applies to: probenecid and Vabomere (meropenem / vaborbactam)

GENERALLY AVOID: Coadministration with probenecid may increase the plasma concentrations of meropenem. The mechanism involves competitive inhibition of the renal excretion of meropenem via active tubular secretion. In pharmacokinetic studies, probenecid increased meropenem systemic exposure (AUC) by 56% and elimination half-life by 38%.

MANAGEMENT: The use of meropenem in combination with probenecid is not recommended by the manufacturer.

References (2)
  1. Bax RP, Bastain W, Featherstone A, Wilkinson DM, Hutchison M, Haworth SJ (1989) "The pharmacokinetics of meropenem in volunteers." J Antimicrob Chemother, 24(suppl a, p. 311-20
  2. (2001) "Product Information. Merrem (meropenem)." Astra-Zeneca Pharmaceuticals

Drug and food interactions

No alcohol/food interactions were found. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

See also

Report options

Loading...
QR code containing a link to this page

Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer