Can you take Polysaccharide Iron with Sodium bicarbonate?
1 drug interaction and 11 additional warnings found for the following 2 drugs:
- Polysaccharide Iron (iron polysaccharide)
- sodium bicarbonate
Drug interactions
Moderate drug interactions
Moderate:
sodium bicarbonate iron polysaccharide
Applies to: sodium bicarbonate and Polysaccharide Iron (iron polysaccharide)
By reducing the acidity level in the stomach, medications like sodium bicarbonate may interfere with the absorption of iron polysaccharide into the bloodstream and reduce its effectiveness.
If you require treatment with both medications, it is recommended that you take iron polysaccharide at least 2 hours before or 2 hours after sodium bicarbonate to help minimize the impact of the interaction.
Talk to your doctor or pharmacist if you have any questions or concerns. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Food/lifestyle interactions
Moderate food/lifestyle interactions
Moderate:
iron polysaccharide Food/Lifestyle
Applies to: Polysaccharide Iron (iron polysaccharide)
Food may reduce the absorption and blood levels of iron polysaccharide. In addition, some oral medications can also interfere with iron polysaccharide absorption into the bloodstream, which may make the medication less effective in treating your condition. Likewise, iron polysaccharide may interfere with the absorption of other orally administered medications.
You should take iron polysaccharide on an empty stomach at least one hour before or two hours after a meal.
Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring to safely use both medications.
Talk to your doctor or pharmacist if you have questions about how to take this or other medications you are prescribed. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Disease interactions
10 potential interactions Applies to: 10 conditions, including Heart Failure, Peptic Ulcer, Fluid Retention, Noninfectious Colitis, and Renal Dysfunction.
Achlorhydria
Moderate:
Polysaccharide Iron
The iron polysaccharide in Polysaccharide Iron has a moderate potential interaction with Achlorhydria.
Gastric acidity increases iron bioavailability by maintaining the ingested iron in a reduced form as ferrous ions, which are more readily absorbed than ferric ions. Therefore, when iron therapy is administered orally, higher dosages may be necessary for patients with decreased gastric acid production. Also, a liquid formulation is recommended in these patients because dissolution of the tablet coating depends on normal gastric acidity.
Alkalosis
Moderate:
sodium bicarbonate
Sodium bicarbonate has a moderate potential interaction with Alkalosis.
Alkalinizing agents act as proton acceptors and/or dissociate to provide bicarbonate ions. Elimination of bicarbonate is decreased in patients with renal impairment and can result in metabolic alkalosis. Symptoms of metabolic alkalosis include hyperirritability or tetany, arrhythmia, and/or seizures (altered pH = altered calcium), or lactic acidosis due to impaired oxygen release. Therapy with alkalinizing agents should be administered with extreme caution in patients with compromised renal function. Clinical monitoring of renal function, acid/base balance and electrolytes is recommended.
Blood Transfusion
Major:
Polysaccharide Iron
The iron polysaccharide in Polysaccharide Iron has a major potential interaction with Blood Transfusion.
There is no excretory mechanism for iron. Iron will correct only hemoglobin abnormalities due to iron deficiency and should not be used to treat conditions such as thalassemia, hemosiderosis, hemochromatosis, normocytic anemia (unless iron deficiency exists), or in patients receiving blood transfusions. Clinical monitoring of erythropoietic function and ferritin levels is recommended.
Fluid Retention
Major:
sodium bicarbonate
Sodium bicarbonate has a major potential interaction with Fluid Retention.
Alkalinizing agents containing sodium can induce sodium and water retention and result in hypernatremia, hypokalemia, hyperosmolality, edema and aggravation of congestive heart failure. Therapy with sodium- containing alkalinizing agents should not be used in patients with hypernatremia or fluid retention. Clinical monitoring of acid/base balance and electrolytes prior to, during, a following completion of therapy with alkalinizing agents is recommended.
Heart Failure
Major:
sodium bicarbonate
Sodium bicarbonate has a major potential interaction with Heart Failure.
Alkalinizing agents containing sodium can induce sodium and water retention and result in hypernatremia, hypokalemia, hyperosmolality, edema and aggravation of congestive heart failure. Therapy with sodium- containing alkalinizing agents should not be used in patients with hypernatremia or fluid retention. Clinical monitoring of acid/base balance and electrolytes prior to, during, a following completion of therapy with alkalinizing agents is recommended.
Hemoglobinopathy
Major:
Polysaccharide Iron
The iron polysaccharide in Polysaccharide Iron has a major potential interaction with Hemoglobinopathy.
There is no excretory mechanism for iron. Iron will correct only hemoglobin abnormalities due to iron deficiency and should not be used to treat conditions such as thalassemia, hemosiderosis, hemochromatosis, normocytic anemia (unless iron deficiency exists), or in patients receiving blood transfusions. Clinical monitoring of erythropoietic function and ferritin levels is recommended.
Hypernatremia
Major:
sodium bicarbonate
Sodium bicarbonate has a major potential interaction with Hypernatremia.
Alkalinizing agents containing sodium can induce sodium and water retention and result in hypernatremia, hypokalemia, hyperosmolality, edema and aggravation of congestive heart failure. Therapy with sodium- containing alkalinizing agents should not be used in patients with hypernatremia or fluid retention. Clinical monitoring of acid/base balance and electrolytes prior to, during, a following completion of therapy with alkalinizing agents is recommended.
Noninfectious Colitis
Moderate:
Polysaccharide Iron
The iron polysaccharide in Polysaccharide Iron has a moderate potential interaction with Noninfectious Colitis.
Iron can be irritating and damaging to gastrointestinal mucosa. Iron therapy should be administered cautiously in patients with peptic ulcer disease, enteritis, or ulcerative colitis.
Peptic Ulcer
Moderate:
Polysaccharide Iron
The iron polysaccharide in Polysaccharide Iron has a moderate potential interaction with Peptic Ulcer.
Iron can be irritating and damaging to gastrointestinal mucosa. Iron therapy should be administered cautiously in patients with peptic ulcer disease, enteritis, or ulcerative colitis.
Renal Dysfunction
Moderate:
sodium bicarbonate
Sodium bicarbonate has a moderate potential interaction with Renal Dysfunction.
Alkalinizing agents act as proton acceptors and/or dissociate to provide bicarbonate ions. Elimination of bicarbonate is decreased in patients with renal impairment and can result in metabolic alkalosis. Symptoms of metabolic alkalosis include hyperirritability or tetany, arrhythmia, and/or seizures (altered pH = altered calcium), or lactic acidosis due to impaired oxygen release. Therapy with alkalinizing agents should be administered with extreme caution in patients with compromised renal function. Clinical monitoring of renal function, acid/base balance and electrolytes is recommended.
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More resources
Polysaccharide Iron
A total of 89 drugs are known to interact with Polysaccharide Iron.
- Polysaccharide iron is in the drug class iron products.
- Polysaccharide iron is used to treat Iron Deficiency Anemia.
sodium bicarbonate
A total of 179 drugs are known to interact with sodium bicarbonate.
- Sodium bicarbonate is in the following drug classes: antacids, minerals and electrolytes, urinary pH modifiers.
- Sodium bicarbonate is used to treat the following conditions:
Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.