Di-Phen Interactions
There are 858 drugs known to interact with Di-Phen (phenytoin), along with 12 disease interactions, and 1 alcohol/food interaction. Of the total drug interactions, 243 are major, 569 are moderate, and 46 are minor.
- View Di-Phen alcohol/food interactions (1)
- View Di-Phen disease interactions (12)
Medications known to interact with Di-Phen
Note: Showing generic names only.
A
- abemaciclib
- abiraterone
- abrocitinib
- acalabrutinib
- acarbose
- acetaminophen
- acetohexamide
- acetylcarbromal
- acoramidis
- acrivastine
- acyclovir
- adagrasib
- adalimumab
- afatinib
- albendazole
- albiglutide
- alefacept
- alfentanil
- allopurinol
- alogliptin
- alpelisib
- alprazolam
- aluminum carbonate
- aluminum hydroxide
- aminophylline
- amiodarone
- amitriptyline
- amlodipine
- amobarbital
- amoxapine
- amphetamine
- amprenavir
- anakinra
- anisindione
- apalutamide
- apixaban
- apomorphine
- apraclonidine ophthalmic
- apremilast
- aprepitant
- aprocitentan
- arbutamine
- aripiprazole
- armodafinil
- artesunate
- asciminib
- asenapine
- ashwaganda
- asparaginase erwinia chrysanthemi
- asparaginase escherichia coli
- aspirin
- atazanavir
- atogepant
- atorvastatin
- atracurium
- atrasentan
- auranofin
- avacopan
- avanafil
- avapritinib
- avatrombopag
- axitinib
- azatadine
- azelastine nasal
B
- baclofen
- bedaquiline
- belumosudil
- benoxinate ophthalmic
- benzocaine topical
- benzphetamine
- benztropine
- bepridil
- berotralstat
- betamethasone
- betrixaban
- bexagliflozin
- bexarotene
- bimekizumab
- binimetinib
- biperiden
- bismuth subsalicylate
- black cohosh
- bleomycin
- blinatumomab
- boceprevir
- bortezomib
- bosentan
- bosutinib
- botulism immune globulin
- brentuximab
- brexanolone
- brexpiprazole
- brigatinib
- brimonidine ophthalmic
- brimonidine topical
- brivaracetam
- brodalumab
- bromfenac
- bromocriptine
- brompheniramine
- budesonide
- bumetanide
- bupivacaine
- bupivacaine liposome
- buprenorphine
- bupropion
- buspirone
- busulfan
- butabarbital
- butalbital
- butorphanol
C
- cabazitaxel
- cabotegravir
- cabozantinib
- calaspargase pegol
- calcifediol
- calcitriol
- calcium carbonate
- canagliflozin
- canakinumab
- cannabidiol
- cannabis
- capecitabine
- capivasertib
- capmatinib
- carbamazepine
- carbetapentane
- carbinoxamine
- carboplatin
- cariprazine
- carisoprodol
- carmustine
- caspofungin
- ceftriaxone
- celecoxib
- cenobamate
- ceritinib
- cetirizine
- cevimeline
- charcoal
- chlophedianol
- chloral hydrate
- chloramphenicol
- chloramphenicol ophthalmic
- chloramphenicol otic
- chlordiazepoxide
- chlormezanone
- chloroprocaine
- chloroprocaine ophthalmic
- chloroquine
- chlorotrianisene
- chlorphenesin
- chlorpheniramine
- chlorpromazine
- chlorpropamide
- chlorzoxazone
- cholecalciferol
- choline salicylate
- cimetidine
- ciprofloxacin
- cisatracurium
- cisplatin
- citalopram
- cladribine
- clarithromycin
- clemastine
- clindamycin
- clobazam
- clofarabine
- clofibrate
- clomipramine
- clonazepam
- clonidine
- clopidogrel
- clorazepate
- clozapine
- cobicistat
- cobimetinib
- cocaine nasal
- cocaine topical
- codeine
- colesevelam
- conjugated estrogens
- conjugated estrogens topical
- copanlisib
- cortisone
- crinecerfont
- crizotinib
- cyclizine
- cyclobenzaprine
- cyclophosphamide
- cycloserine
- cyclosporine
- cyproheptadine
- cytomegalovirus immune globulin
D
- dabigatran
- dabrafenib
- daclatasvir
- daclizumab
- dantrolene
- dapsone topical
- daridorexant
- darifenacin
- darolutamide
- darunavir
- dasatinib
- deferasirox
- deflazacort
- delavirdine
- desipramine
- desvenlafaxine
- deutetrabenazine
- dexamethasone
- dexbrompheniramine
- dexmedetomidine
- dexmethylphenidate
- dextroamphetamine
- dextromethorphan
- dezocine
- diazepam
- diazoxide
- dibucaine topical
- dicumarol
- dienestrol topical
- difelikefalin
- digitoxin
- digoxin
- dihydroergotamine
- dihydrotachysterol
- dihydroxyaluminum sodium carbonate
- diltiazem
- dimenhydrinate
- diphenhydramine
- disopyramide
- disulfiram
- divalproex sodium
- docetaxel
- dofetilide
- dolutegravir
- donepezil
- dopamine
- doravirine
- doxacurium
- doxepin
- doxepin topical
- doxercalciferol
- doxorubicin
- doxorubicin liposomal
- doxycycline
- doxylamine
- dronabinol
- dronedarone
- droperidol
- drospirenone
- dulaglutide
- duloxetine
- duvelisib
E
- edoxaban
- efavirenz
- elacestrant
- elagolix
- eliglustat
- elranatamab
- elvitegravir
- emapalumab
- empagliflozin
- encorafenib
- enfortumab vedotin
- entacapone
- entrectinib
- enzalutamide
- epcoritamab
- epirubicin
- eplerenone
- eravacycline
- erdafitinib
- ergocalciferol
- ergonovine
- ergotamine
- erlotinib
- ertugliflozin
- erythromycin
- escitalopram
- esketamine
- eslicarbazepine
- esomeprazole
- estazolam
- esterified estrogens
- estradiol
- estradiol topical
- estrone
- estropipate
- estropipate topical
- eszopiclone
- ethacrynic acid
- ethanol
- ethchlorvynol
- ethinyl estradiol
- ethosuximide
- etidocaine
- etonogestrel
- etoposide
- etranacogene dezaparvovec
- etravirine
- evening primrose
- everolimus
- exemestane
- exenatide
- ezogabine
F
- famotidine
- febuxostat
- fedratinib
- felbamate
- felodipine
- fenfluramine
- fenofibrate
- fentanyl
- fesoterodine
- fexinidazole
- fidanacogene elaparvovec
- finerenone
- flavoxate
- flibanserin
- fluconazole
- fludrocortisone
- fluorouracil
- fluoxetine
- fluphenazine
- flurazepam
- fluvoxamine
- folic acid
- fosamprenavir
- fosaprepitant
- fostamatinib
- fostemsavir
- fruquintinib
- furosemide
- futibatinib
G
- gabapentin
- gabapentin enacarbil
- ganaxolone
- gefitinib
- gepirone
- gilteritinib
- ginkgo
- glasdegib
- glimepiride
- glipizide
- glofitamab
- glyburide
- golimumab
- guanfacine
- guselkumab
H
- halazepam
- haloperidol
- halothane
- hemin
- hepatitis b immune globulin
- heroin
- hydrocodone
- hydrocortisone
- hydromorphone
- hydroxychloroquine
- hydroxyprogesterone
- hydroxyzine
I
- ibrexafungerp
- ibrutinib
- ibuprofen
- idelalisib
- iloperidone
- imatinib
- imipramine
- immune globulin intramuscular
- immune globulin intravenous
- immune globulin intravenous and subcutaneous
- immune globulin subcutaneous
- indinavir
- infigratinib
- infliximab
- influenza virus vaccine, inactivated
- insulin
- insulin aspart
- insulin aspart protamine
- insulin degludec
- insulin detemir
- insulin glargine
- insulin glulisine
- insulin inhalation, rapid acting
- insulin isophane
- insulin lispro
- insulin lispro protamine
- insulin regular
- insulin zinc
- insulin zinc extended
- interferon beta-1a
- interferon beta-1b
- irinotecan
- irinotecan liposomal
- isavuconazonium
- isocarboxazid
- isoniazid
- isotretinoin
- isradipine
- istradefylline
- itraconazole
- ivabradine
- ivacaftor
- ivosidenib
- ixabepilone
- ixazomib
K
L
- l-methylfolate
- lacosamide
- lamotrigine
- lanthanum carbonate
- lapatinib
- larotrectinib
- lasmiditan
- lazertinib
- lefamulin
- leflunomide
- lemborexant
- lenacapavir
- leniolisib
- lesinurad
- letermovir
- leucovorin
- levamisole
- levamlodipine
- levobupivacaine
- levocetirizine
- levodopa
- levoketoconazole
- levoleucovorin
- levomefolate calcium
- levomethadyl acetate
- levonorgestrel
- levorphanol
- levothyroxine
- levothyroxine / liothyronine
- lidocaine
- lidocaine ophthalmic
- lidocaine otic
- lidocaine topical
- linagliptin
- liothyronine
- liotrix
- liraglutide
- lisdexamfetamine
- lithium
- lixisenatide
- lofexidine
- lomitapide
- lonafarnib
- lorazepam
- lorlatinib
- losartan
- loxapine
- lumateperone
- lurasidone
- lurbinectedin
M
- macimorelin
- macitentan
- magaldrate
- magnesium carbonate
- magnesium hydroxide
- magnesium oxide
- magnesium salicylate
- maprotiline
- maraviroc
- maribavir
- mavacamten
- mavorixafor
- mebendazole
- meclizine
- medroxyprogesterone
- mefloquine
- megestrol
- melatonin
- meperidine
- mephobarbital
- mepivacaine
- meprobamate
- mercaptopurine
- mesoridazine
- metaxalone
- metformin
- methadone
- methamphetamine
- methdilazine
- methocarbamol
- methohexital
- methotrexate
- methotrimeprazine
- methsuximide
- methylergonovine
- methylphenidate
- methylprednisolone
- methysergide maleate
- metoclopramide
- metocurine
- metronidazole
- metyrosine
- mexiletine
- mibefradil
- miconazole
- midazolam
- midostaurin
- mifepristone
- miglitol
- mipomersen
- mirabegron
- mirtazapine
- mitapivat
- mitotane
- mivacurium
- mobocertinib
- modafinil
- molindone
- momelotinib
- montelukast
- morphine
- morphine liposomal
- mosunetuzumab
- multivitamin, prenatal
- mycophenolate mofetil
- mycophenolic acid
N
- nabilone
- nafcillin
- nalbuphine
- naldemedine
- naloxegol
- naltrexone
- nateglinide
- nelfinavir
- nemolizumab
- neratinib
- nevirapine
- nicardipine
- nifedipine
- nilotinib
- nimodipine
- nintedanib
- nirogacestat
- nisoldipine
- nitazoxanide
- nitisinone
- nitrofurantoin
- norethindrone
- norgestrel
- nortriptyline
O
- olanzapine
- olaparib
- oliceridine
- olopatadine nasal
- olutasidenib
- omaveloxolone
- omeprazole
- ondansetron
- opicapone
- opium
- oritavancin
- orphenadrine
- osilodrostat
- osimertinib
- ospemifene
- oxazepam
- oxcarbazepine
- oxtriphylline
- oxycodone
- oxymorphone
P
- paclitaxel
- paclitaxel protein-bound
- pacritinib
- palbociclib
- paliperidone
- palovarotene
- pancuronium
- panobinostat
- paraldehyde
- paricalcitol
- paroxetine
- pazopanib
- pegaspargase
- peginterferon beta-1a
- pemigatinib
- pemoline
- pentazocine
- pentobarbital
- perampanel
- pergolide
- perphenazine
- pexidartinib
- phenelzine
- phenindamine
- phenobarbital
- phensuximide
- pimavanserin
- pimozide
- pioglitazone
- pipecuronium
- pirfenidone
- pirtobrutinib
- pitolisant
- polatuzumab vedotin
- pomalidomide
- ponatinib
- ponesimod
- posaconazole
- pralsetinib
- pramipexole
- pramlintide
- pramoxine topical
- praziquantel
- prednisolone
- prednisone
- pregabalin
- pretomanid
- prilocaine
- primidone
- procaine
- procaine penicillin
- prochlorperazine
- procyclidine
- progesterone
- progesterone topical
- promazine
- promethazine
- proparacaine ophthalmic
- propiomazine
- propoxyphene
- protriptyline
- pyridoxine
- pyrilamine
Q
R
- rabies immune globulin, human
- raltegravir
- ramelteon
- ranitidine
- ranitidine bismuth citrate
- ranolazine
- rapacuronium
- rasagiline
- regorafenib
- relugolix
- remdesivir
- remifentanil
- remimazolam
- repaglinide
- repotrectinib
- respiratory syncytial virus immune globulin
- revumenib
- rho (d) immune globulin
- ribociclib
- rifabutin
- rifampin
- rifapentine
- rilonacept
- rilpivirine
- rimegepant
- riociguat
- ripretinib
- risperidone
- ritlecitinib
- ritonavir
- rivaroxaban
- rocuronium
- roflumilast
- rolapitant
- romidepsin
- ropeginterferon alfa-2b
- ropinirole
- ropivacaine
- rosiglitazone
- rotigotine
- rucaparib
- rufinamide
- ruxolitinib
- ruxolitinib topical
S
- sacituzumab govitecan
- safinamide
- salsalate
- saquinavir
- sarilumab
- satralizumab
- saxagliptin
- scopolamine
- secobarbital
- secukinumab
- seladelpar
- selegiline
- selexipag
- selinexor
- selpercatinib
- selumetinib
- semaglutide
- sertraline
- sibutramine
- sildenafil
- silodosin
- siltuximab
- silver nitrate topical
- silver sulfadiazine topical
- simeprevir
- siponimod
- sirolimus
- sirolimus protein-bound
- sitagliptin
- sodium bicarbonate
- sodium citrate
- sodium nitrite
- sodium oxybate
- sodium salicylate
- sodium thiosalicylate
- sofosbuvir
- solifenacin
- sonidegib
- sorafenib
- sotagliflozin
- sotorasib
- sparsentan
- st. john's wort
- stiripentol
- succinylcholine
- sucralfate
- sufentanil
- sulfadiazine
- sulfadoxine
- sulfamethizole
- sulfamethoxazole
- sulfasalazine
- sulfinpyrazone
- sulfisoxazole
- sunitinib
- suvorexant
- suzetrigine
T
- tacrolimus
- tadalafil
- talquetamab
- tamoxifen
- tapentadol
- tarlatamab
- tasimelteon
- tazemetostat
- tebentafusp
- teclistamab
- telaprevir
- telithromycin
- temazepam
- temsirolimus
- teniposide
- tenofovir alafenamide
- tenofovir disoproxil
- tepotinib
- teriflunomide
- tetanus immune globulin
- tetrabenazine
- tetracaine
- tetracaine ophthalmic
- tetracaine topical
- thalidomide
- thallous chloride, tl-201
- theophylline
- thiethylperazine
- thioguanine
- thioridazine
- thiotepa
- thiothixene
- thyroid desiccated
- tiagabine
- ticagrelor
- ticlopidine
- tinidazole
- tipranavir
- tirzepatide
- tisotumab vedotin
- tivozanib
- tizanidine
- tocilizumab
- tofacitinib
- tolazamide
- tolbutamide
- tolcapone
- tolvaptan
- topiramate
- toremifene
- torsemide
- trabectedin
- tramadol
- tranylcypromine
- trazodone
- treprostinil
- tretinoin
- triamcinolone
- triazolam
- trifluoperazine
- triflupromazine
- trihexyphenidyl
- trimeprazine
- trimethobenzamide
- trimethoprim
- trimipramine
- tripelennamine
- triprolidine
- troglitazone
- troleandomycin
- tubocurarine
- tucatinib
U
V
- vaccinia immune globulin
- vadadustat
- valbenazine
- valdecoxib
- valerian
- valoctocogene roxaparvovec
- valproic acid
- vamorolone
- vandetanib
- varicella zoster immune globulin
- vecuronium
- vemurafenib
- venetoclax
- venlafaxine
- verapamil
- vigabatrin
- vilazodone
- vinblastine
- vincristine
- vincristine liposome
- vinorelbine
- voclosporin
- vonoprazan
- vorapaxar
- vorasidenib
- voriconazole
- vortioxetine
- voxelotor
W
Z
Di-Phen alcohol/food interactions
There is 1 alcohol/food interaction with Di-Phen (phenytoin).
Di-Phen disease interactions
There are 12 disease interactions with Di-Phen (phenytoin) which include:
- blood dyscrasias
- liver disease
- porphyria
- renal dysfunction
- cardiotoxicity
- suicidal tendency
- arrhythmias
- hyperglycemia
- megaloblastic anemia
- osteomalacia
- alcoholism
- thyroid function tests
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More about Di-Phen (phenytoin)
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.