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Drug Interactions between Pacerone and Probuphine

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Moderate

amiodarone buprenorphine

Applies to: Pacerone (amiodarone) and Probuphine (buprenorphine)

Amiodarone can increase the blood levels and effects of buprenorphine. Contact your doctor if you experience dizziness, fainting, confusion, excessive drowsiness, slow heart rate, shallow or difficult breathing, and/or shortness of breath. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Avoid driving or operating hazardous machinery until you know how the medications affect you, and use caution when getting up from a sitting or lying position. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

The following also applies if you are receiving buprenorphine in the form of a skin patch for pain:
Talk to your doctor before using the skin patch together with amiodarone. Combining these medications can increase the risk of an irregular heart rhythm that may be serious, especially if you are on a higher dosage of the patch. You should seek immediate medical attention if you develop sudden dizziness, lightheadedness, fainting, or fast or pounding heartbeats during treatment with these medications, whether together or alone. Do not use more of these medications than what your doctor prescribed.

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Drug and food interactions

Major

amiodarone food

Applies to: Pacerone (amiodarone)

Amiodarone may be taken with or without food but should be taken at the same way each time. You should avoid consuming grapefruits and grapefruit juice while taking amiodarone. Do not increase or decrease the amount of grapefruit products in your diet without first talking to your doctor. Grapefruit can raise the levels of amiodarone in your body and lead to dangerous side effects. This can affect the rhythm of your heart. Call your doctor if you have symptoms of irregular heartbeat, chest tightness, blurred vision or nausea.

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Major

buprenorphine food

Applies to: Probuphine (buprenorphine)

Using buprenorphine together with other medications that also cause central nervous system depression can lead to serious side effects such as respiratory distress, coma, and even death. Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring to safely use both medications. Do not drink alcohol or self-medicate with these medications without your doctor's approval, and do not exceed the doses or frequency and duration of use prescribed by your doctor. Also, you should avoid driving or operating hazardous machinery until you know how these medications affect you. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

See also

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer