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Drug Interactions between oxymorphone and Viagra

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Moderate

oxyMORphone sildenafil

Applies to: oxymorphone and Viagra (sildenafil)

Limited evidence suggests that use of narcotic medications like oxyMORphone may increase the effects of sildenafil. Rarely, there have been reports of prolonged erections lasting 2 to 5 hours. Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Drug and food/lifestyle interactions

Major

oxyMORphone food/lifestyle

Applies to: oxymorphone

Consumer information for this interaction is not currently available.

GENERALLY AVOID: Consumption of alcohol while taking immediate- or extended-release formulations of oxymorphone may result in high systemic levels of oxymorphone and fatal overdose even in opioid-tolerant patients. Additionally, alcohol may potentiate the central nervous system (CNS) depressant effects of opioid analgesics including oxymorphone. Concomitant use may result in additive CNS depression and impairment of judgment, thinking, and psychomotor skills. In more severe cases, hypotension, respiratory depression, profound sedation, coma, or even death may occur.

ADJUST DOSING INTERVAL: After oral dosing with 40 mg of oxymorphone hydrochloride in healthy volunteers under fasting conditions or with a high-fat meal, the maximum plasma concentration (Cmax) and systemic exposure (AUC) of oxymorphone were increased by approximately 38% in fed subjects compared to fasted subjects.

MANAGEMENT: Patients taking opioid analgesics including oxymorphone should not consume alcohol or use medications that contain alcohol. Modified and/or extended-release oxymorphone formulations must also be swallowed whole and not crushed, chewed or divided. In addition, oxymorphone should be administered on an empty stomach, at least 1 hour before or 2 hours after food intake.

Moderate

sildenafil food/lifestyle

Applies to: Viagra (sildenafil)

If you are receiving therapy with sildenafil you should avoid the regular consumption of large amounts of grapefruits and grapefruit juice. Grapefruit can raise the levels of sildenafil in your body and delay the time it takes for the medication to work. Do not increase or decrease the amount of grapefruit products in your diet without first talking to your doctor.

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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