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Drug Interactions between olanzapine / samidorphan and oritavancin

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Moderate

oritavancin samidorphan

Applies to: oritavancin and olanzapine / samidorphan

MONITOR: Coadministration with inducers of CYP450 3A4 may decrease the plasma concentrations of samidorphan. According to the prescribing information, samidorphan is primarily metabolized by CYP450 3A4, with minor contributions from CYP450 2C8, 2C19, and 3A5. When olanzapine-samidorphan was coadministered with rifampin, a potent CYP450 3A4 inducer, samidorphan peak plasma concentration (Cmax) and systemic exposure (AUC) decreased by 44% and 73%, respectively. Olanzapine Cmax and AUC also decreased by 11% and 48%, respectively, most likely due to induction of CYP450 1A2 and/or uridine diphosphate glucuronosyltransferase (UGT) 1A4 by rifampin. The interaction has not been studied with other, less potent inducers.

MANAGEMENT: The potential for diminished pharmacologic effects of samidorphan and possibly also olanzapine should be considered during coadministration with CYP450 3A4 inducers. Alternative treatments may be required if an interaction is suspected.

References (1)
  1. (2021) "Product Information. Lybalvi (olanzapine-samidorphan)." Alkermes, Inc

Drug and food interactions

Moderate

OLANZapine food

Applies to: olanzapine / samidorphan

GENERALLY AVOID: Alcohol may potentiate some of the pharmacologic effects of CNS-active agents. Use in combination may result in additive central nervous system depression and/or impairment of judgment, thinking, and psychomotor skills.

MANAGEMENT: Patients receiving CNS-active agents should be warned of this interaction and advised to avoid or limit consumption of alcohol. Ambulatory patients should be counseled to avoid hazardous activities requiring complete mental alertness and motor coordination until they know how these agents affect them, and to notify their physician if they experience excessive or prolonged CNS effects that interfere with their normal activities.

References (4)
  1. Warrington SJ, Ankier SI, Turner P (1986) "Evaluation of possible interactions between ethanol and trazodone or amitriptyline." Neuropsychobiology, 15, p. 31-7
  2. Gilman AG, eds., Nies AS, Rall TW, Taylor P (1990) "Goodman and Gilman's the Pharmacological Basis of Therapeutics." New York, NY: Pergamon Press Inc.
  3. (2012) "Product Information. Fycompa (perampanel)." Eisai Inc
  4. (2015) "Product Information. Rexulti (brexpiprazole)." Otsuka American Pharmaceuticals Inc

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

See also

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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