Drug Interactions between mobocertinib and roflumilast
This report displays the potential drug interactions for the following 2 drugs:
- mobocertinib
- roflumilast
Interactions between your drugs
No interactions were found between mobocertinib and roflumilast. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.
mobocertinib
A total of 518 drugs are known to interact with mobocertinib.
- Mobocertinib is in the drug class EGFR inhibitors.
- Mobocertinib is used to treat Non-Small Cell Lung Cancer.
roflumilast
A total of 344 drugs are known to interact with roflumilast.
- Roflumilast is in the drug class selective phosphodiesterase-4 inhibitors.
- Roflumilast is used to treat the following conditions:
Drug and food interactions
mobocertinib food
Applies to: mobocertinib
GENERALLY AVOID: Grapefruit juice may increase the plasma concentrations of mobocertinib. The mechanism may involve inhibition of CYP450 3A4-mediated first-pass metabolism in the gut wall by certain compounds present in grapefruit. Inhibition of hepatic CYP450 3A4 may also contribute. The interaction has not been studied with grapefruit juice. Based on drug interaction studies using model-informed approaches, coadministration of mobocertinib with multiple doses of itraconazole or ketoconazole (strong CYP450 3A4 inhibitors) is predicted to increase the steady-state combined molar AUC (systemic exposure) of mobocertinib and its active metabolites by 374% to 419%, while coadministration with multiple doses of a moderate CYP450 3A4 inhibitor is predicted to increase this value by approximately 100% to 200%. In general, the effect of grapefruit juice is concentration-, dose- and preparation-dependent, and can vary widely among brands. Certain preparations of grapefruit juice (e.g., high dose, double strength) have sometimes demonstrated potent inhibition of CYP450 3A4, while other preparations (e.g., low dose, single strength) have typically demonstrated moderate inhibition. Elevated plasma concentrations of mobocertinib may increase the risk for adverse effects such as QT prolongation, heart failure or reduced ejection fraction, cardiomyopathy, heart block, diarrhea, rash, stomatitis, fatigue, and musculoskeletal pain.
MANAGEMENT: Patients should avoid consumption of grapefruit and grapefruit juice during treatment with mobocertinib.
References
- (2021) "Product Information. Exkivity (mobocertinib)." Takeda Pharmaceuticals America
- (2022) "Product Information. Exkivity (mobocertinib)." Takeda UK Ltd
roflumilast food
Applies to: roflumilast
Food intake does not affect the total exposure to roflumilast and its pharmacologically active N-oxide metabolite, but delays the time to maximum concentration (Tmax) of roflumilast by one hour and reduces its peak plasma concentration (Cmax) by approximately 40%. The Tmax and Cmax of
roflumilast N-oxide are unaffected. Roflumilast may be taken with or without food.
References
- Cerner Multum, Inc. "UK Summary of Product Characteristics."
- (2011) "Product Information. Daxas (roflumilast)." Nycomed Inc
- (2011) "Product Information. Daliresp (roflumilast)." Astra-Zeneca Pharmaceuticals
Therapeutic duplication warnings
No warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
See also
Drug Interaction Classification
Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
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