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Drug Interactions between mitomycin and vinorelbine

This report displays the potential drug interactions for the following 2 drugs:

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Moderate

mitoMYcin vinorelbine

Applies to: mitomycin and vinorelbine

MONITOR: Acute shortness of breath and severe bronchospasm have been reported following the administration of vinca alkaloids. These reactions have been encountered most frequently when the vinca alkaloid was used in combination with mitomycin-C. The exact mechanism of the interaction is not known. The reaction may within occur several minutes to 2 weeks after administration of the vinca alkaloid.

MANAGEMENT: The acute shortness of breath and severe bronchospasm may require aggressive treatment (particularly if there is preexisting pulmonary dysfunction). Progressive dyspnea requiring chronic therapy may occur. The vinca alkaloid should not be readministered.

References (7)
  1. Israel RH, Olson JP (1978) "Pulmonary edema associated with intravenous vinblastine." JAMA, 240, p. 1585
  2. Ozols RF, Hogan WM, Ostchega Y, Young RC (1983) "MVP (mitomycin, vinblastine, and progesterone): a second-line regimen in ovarian cancer with a high incidence of pulmonary toxicity." Cancer Treat Rep, 67, p. 721-2
  3. Dyke RW (1984) "Acute bronchospasm after a vinca alkaloid in patients previously treated with mitomycin." N Engl J Med, 310, p. 389
  4. Kris MG, Pablo D, Gralla RJ, Burke MT, Prestifillippo J, Lewin D (1984) "Dyspnea following vinblastine or vindesine administration in patients receiving mitomycin plus vinca alkaloid combination therapy." Cancer Treat Rep, 68, p. 1029-31
  5. Rao SX, Ramaswamy G, Levin M, McCravey JW (1985) "Fatal acute respiratory failure after vinblastine-mitomycin therapy in lung carcinoma." Arch Intern Med, 145, p. 1905-7
  6. Holzer KL, Harrison BR, Luedke SW, Luedke DW (1986) "Vinblastine-associated pulmonary toxicity in patients receiving combination therapy with mitomycin and cisplatin." Drug Intell Clin Pharm, 20, p. 287-9
  7. Konits PH, Aisner J, Sutherland JC, Wiernik PH (1982) "Possible pulmonary toxicity secondary to vinblastine." Cancer, 50, p. 2771-4

Drug and food interactions

No alcohol/food interactions were found. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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