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Drug Interactions between misoprostol and oxytocin

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Major

miSOPROStol oxytocin

Applies to: misoprostol and oxytocin

ADJUST DOSING INTERVAL: Prostaglandins, especially those of the E type such as misoprostol, may potentiate the uterine response to oxytocin and increase the risk of uterine hyperstimulation and rupture. The mechanism of interaction is unknown.

MANAGEMENT: In the countries where it is indicated for the induction of labor or termination of pregnancy, the use of misoprostol in combination with oxytocin and other oxytocic agents is considered contraindicated (GB). Infusion of oxytocin should not be started until at least 4 hours after the last dose of misoprostol oral tablet or at least 6 to 12 hours after the insertion of a misoprostol vaginal tablet. Recommended time intervals vary by brand and manufacturer. It is recommended to refer to local guidelines or drug product labeling. As cervical trauma can occur without remarkable symptomatology, each patient should also be carefully examined postabortion.

References (4)
  1. Cerner Multum, Inc. "UK Summary of Product Characteristics."
  2. Agencia Española de Medicamentos y Productos Sanitarios Healthcare (2008) Centro de información online de medicamentos de la AEMPS - CIMA. https://cima.aemps.es/cima/publico/home.html
  3. Instituto de Salud Pública de Chile (2013) Sistema de Consulta de Productos Registrados. http://registrosanitario.ispch.gob.cl/
  4. Cerner Multum, Inc (2015) "ANVISA Bulário Eletrônico."

Drug and food interactions

No alcohol/food interactions were found. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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