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Drug Interactions between mexiletine and Solarcaine Burn Relief

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Moderate

mexiletine lidocaine topical

Applies to: mexiletine and Solarcaine Burn Relief (lidocaine topical)

MONITOR: Coadministration of topical formulations containing lidocaine with class IB antiarrhythmic agents such as mexiletine or tocainide may have additive and potentially synergistic toxic effects. Mexiletine, tocainide and lidocaine are structural analogs, and all have antiarrhythmic effects. The clinical significance of the interaction has not been established; the degree of systemic absorption of topical lidocaine may be dependent on the duration of application and the applied surface area.

MANAGEMENT: Caution and clinical monitoring is recommended with the concomitant use of lidocaine-containing topical formulations and class IB antiarrhythmic drugs (e.g., mexiletine, tocainide). Advise patients to contact their physician if they experience adverse effects such as chest pain, palpitations, nausea, vomiting, lightheadedness, nervousness, dizziness or tremors.

References

  1. (2001) "Product Information. Lidoderm (lidocaine topical)." Endo Laboratories LLC
  2. (2022) "Product Information. Oraqix (lidocaine-prilocaine topical)." Dentsply Pharmaceuticals, 1
  3. (2022) "Product Information. Diclona (diclofenac-lidocaine topical)." Terrain Pharmaceuticals, 1

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Drug and food interactions

No alcohol/food interactions were found. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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