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Drug Interactions between methotrexate and Okebo

This report displays the potential drug interactions for the following 2 drugs:

  • methotrexate
  • Okebo (doxycycline)

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Interactions between your drugs

Moderate

doxycycline methotrexate

Applies to: Okebo (doxycycline) and methotrexate

Before using doxycycline, tell your doctor if you also use methotrexate. Doxycycline may increase or decrease the blood levels and side effects of methotrexate. Contact your doctor right away if you develop flu-like symptoms (fever, chills, body aches, sore throat, muscle weakness), any other signs of infection, pale skin, easy bruising or bleeding, diarrhea, or mouth sores. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Drug and food interactions

Moderate

methotrexate food

Applies to: methotrexate

Caffeine may reduce the effectiveness of methotrexate in the treatment of arthritis. If you are receiving methotrexate for arthritis, you may want to limit your intake of caffeine-containing foods and medications. Check with your doctor or pharmacist if you have concerns or are uncertain what products may contain caffeine.

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Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.